SARS-CoV-2 orthologs of pathogenesis-involved small viral RNAs of SARS-CoV
SSARS-CoV-2 orthologs of pathogenesis-involvedsmall viral RNAs of SARS-CoV
Ali Ebrahimpour Boroojeny and Hamidreza ChitsazDepartment of Computer Science, Colorado State University http://[email protected]
AbstractBackground
The COVID-19 pandemic clock is ticking and the survival of many ofmankind’s modern institutions and or survival of many individuals is at stake. There is aneed for treatments to significantly reduce the morbidity and mortality of COVID-19.Hence, we delved deep into the SARS-CoV-2 genome, which is the virus that has causedCOVID-19. SARS-CoV-2 is from the same family as SARS-CoV in which three small viralRNAs (svRNA) were recently identified [1]; those svRNAs play a significant role in the viruspathogenesis in mice.
Contribution
In this paper, we report potential orthologs of those three svRNAs in theSARS-CoV-2 genome. Instead of off-the-shelf search and alignment algorithms, which failedto discover the orthologs, we used a special alignment scoring that does not penalize C/Tand A/G mismatches. RNA bases C and U both can bind to G; similarly, A and G both canbind to U, hence, our scoring.To validate our results, we confirmed the discovered orthologs are fully conserved inall the publicly available genomes of various strains of SARS-CoV-2; the loci at which theSARS-CoV-2 orthologs occur are close to the loci at which SARS-CoV svRNAs occur. Wealso report potential targets for these svRNAs. We hypothesize that the discovered orthologsplay a role in pathogenesis of SARS-CoV-2, and therefore, antagomir-mediated inhibition ofthese SARS-CoV-2 svRNAs inhibits COVID-19.
The world is now struggling with a pandemic known as COVID-19 which is caused by a novelcoronavirus that was first identified in December 2019 in a local sea food market in Wuhan,China [2]. Due to the similarity of its genomic sequence to that of Severe Acute RespiratorySyndrome (SARS-CoV), which is a member of the subgenus of Sarbecovirus, the aforementionednovel coronavirus was named SARS-CoV-2. Phylogenetic studies have found a bat origin forthis virus [3, 4]. As of April th , , this virus has infected more than 3,150,000 people in185 countries, caused more than 227,000 cases of death, and has become a global health concernleading to massive lock downs and quarantine all around the world.1 a r X i v : . [ q - b i o . GN ] J u l ince the emergence of SARS-CoV in China in 2002, which infected around 8,000 peopleworld-wide, multiple research efforts have tried to understand that virus and to suggest potentialtreatments. Despite the fact that no vaccines or antivirals have been approved to date for any ofcoronaviruses, improvements on reducing the severity of the disease and mortality rate have beenreported. Because of the similarity of the recent fast-spreading coronavirus SARS-CoV-2, whichshares more than of its genomic sequence with SARS-CoV, one plausible way to understandhow it works and suggest possible treatments would be to port what has been found for SARS-CoVpreviously to SARS-CoV-2.Non-coding RNAs (ncRNAs) are, as the name suggests, RNAs that do not translate to proteins.Although it is likely the case that some of them do not play a major role in the cell [5, 6], somehave crucial functions, such as transfer RNAs (tRNAs), ribosomal RNAs (rRNAs), micro RNAs(miRNAs), etc. Some of the ncRNAs, such as miRNAs, play a role in post-transcriptional regulationof gene expression. They, through a procedure called gene silencing, bind with the complementaryparts of the target RNAs, and prevent the translation of those RNAs through cleavage of theirstrand, shortening their poly-A tail, or downgrading the efficiency of their translation by makingsome nucleotides unavailable to the ribosomes [7, 8].First viral ncRNA was identified by Reich et al. [9]. Since then a plethora of viral-associatedncRNAs have been identified and this has been accelerated by the advances in technology [10].Especially, deep sequencing has facilitated the detection of small virus-associated RNAs [11, 12].Some of these ncRNAs are known to be responsible in counteracting the antiviral defense mechinismthat are present in the host cells, mostly through inhibition of protein kinase R (PKR) [13].Therefore, they aid in the life cycle of the virus [14, 15], such as svRNAs in influenza A virus thatare involved in the mechanisms this virus uses for switching between transcription and replication[12].It had been well-known that nuclear and DNA viruses encode miRNAs [16] that play a role inpersistence [17] of the virus as well as changing the transcriptopme in the host cell [18]. Using thedeep sequencing technologies, it had been revealed that cytoplasmic RNA viruses also expressncRNAs [11, 12, 1] and most of them induce various cytoplasmic pathways to express their ncRNAs[12]. Flaviviruses can be mentioned as examples of cytoplasmic RNA viruses, which are verysensitive to interferons and have evolved a variety of mechanisms to avoid their action [19]. It hasbeen shown that ncRNAs in flaviviral RNA bounds to genes responsible for regulation of antiviralstate of the host cell and affects the interferon response agains the virus [20].A recent research has reported three small viral RNAs (svRNAs) that are derived from thegenomic regions of SARS-CoV [1]. Morales et al. have have shown the presence of these positivesense svRNAs, which are “mapped to nsp3 at the (cid:48) end of the Replicase gene and the N gene(svRNA-N) at the (cid:48) end of the genomic RNA (gRNA)” [1], by using specific small RNA RT-qPCRassays. Their experiments on a mouse model of the infection [21, 22] show that these svRNAscontribute to SARS-CoV pathogenesis, and also suggest a potential antiviral treatment usingantagomir-mediated inhibition of these svRNAs.Small non-coding RNAs that play an improtant roll have been shown to be highly conservedamong genuses and families. Given that SARS-CoV-2 is in the the same subgenus as SARS-CoVand their genomic sequence has more than similarity, if orthologs of the svRNAs found inSARS-CoV be present and found in SARS-CoV-2, then (antagomir-mediated) inhibition of thosesvRNA orthologs is expected to lead to reduction of SARS-CoV-2 titers and help decrease severityof COVID-19 in the majority of patients, as was shown to be the case for SARS-CoV [1]. What isneeded is the sequence of the three aforementioned svRNAs in SARS-CoV-2 genome, from which2he corresponding antagomirs are simply designed through base pair complementarity.To target SARS-CoV-2 svRNAs, we first characterize the sequence of three svRNAs in SARS-CoV-2. We achieve that goal by aligning the sequences of SARS-CoV svRNAs to the SARS-CoV-2genome sequences. After investigating many of the available sequenced genomes of SARS-CoV-2that have been reported in various locations around the globe, we discovered the presence of threesvRNAs that were highly conserved orthologs of the svRNAs that played a role in pathogenesisof SARS-CoV. This in silico discovery still needs to be confirmed using in vitro and in vivo experiments, but our findings reported in the following sections suggest strong likelihood of ourhypothesis. In order to find the svRNAs in SARS-Cov-2 that are orthologs of those in SARS-CoV, we selectedall of the complete genomic sequences of SARS-CoV-2, that were made available on the NCBIportal as of March th (173 complete sequences) as well as 27 more randomly chosen ones amongthe more recent uploads on the NCBI portal. These genomic sequences are from different statesand countries, including but not limited to: New York, Washington, California, Illinois, Utah,China, Japan, South Korea, Italy, India, Brazil, Germany, Australia, Turkey, and Greece.We used a variant of the algorithm introduced by Smith and Waterman, which is known in thecommunity as the fit alignment [23], as the core of investigation for the svRNAs of interest. Thealgorithm devised by Smith and Waterman is itself a variant of the global alignment algorithmknown as Needleman-Wunsch algorithm [24], and can be used to find the regions of two genomicsequences that are similar. Fit alignment is a variant of this algorithm that searches a referencegenome for a subsection that is highly similar to another shorter sequence.We used our own in-house alignment tool that implements a faster variant of local and fitalignment algorithms, based on the idea of limiting the search to considering only a subset of thealignment search space that represents high similarity and pruning the regions that fall below thedesired threshold. Also, when aligning two sequences, there might be multiple alignments with thesame score as the highest score. Therefore, our tool keeps track of all the alignments with a scoreequal to the highest score. For this specific problem, we also added the feature of choosing thebest alignment that exists in all the other reference sequences. However, we should note that, forall the sequences considered (the ones in Table 1) the loci reported for the exact match to oursuggested svRNAs have also the highest score of alignment with the svRNAs reported by Morales et al. in their respective sequence. Figures 1, 2, and 3 show the sequences that we have found for three svRNAs in SARS-CoV-2 thatare orthologs of the three aforementioned svRNAs in SARS-CoV. To further test our hypothesis,we searched for all these svRNAs in 200 different complete reference sequences of the virus. Ourthree svRNAs are wholly present, without any mutation, in all the reference sequences. Table 1shows the NCBI ID of each of these sequences, as well as the string loci of each of the svRNAs. Asyou can see 199 out of 200 tested sequences are present in the table and contain the exact matchof the proposed RNAs. The missing entry of the table is LR757997 which showed the presence ofthe third svRNA at loci 28604 but does not contain the other two because there is a gap in the3equence from loci 3001 to 3235 (filled with Ns), and this is the region where the first two svRNAsreside in according to the loci values in the table for these two columns.We identify a non-detrimental mismatch by : in Figures 1, 2, and 3. RNA-RNA binding energiesis mainly governed by Watson-Crick base pairing, namely A-U, G-U, and C-G. Particularly, Ucan pair with both A and G. Hence, an A vs. G mismatch (substitution) in an ortholog RNA isnon-detrimental for the binding to a target RNA. Similarly, G can pair with both U and C. Hence,an U/T vs. C mismatch (substitution) in an ortholog RNA is non-detrimental for the binding to atarget RNA. GAGGAAGAAG−AGGACGATGATGAAGAAGAAGG−TGAT
Figure 1: Alignment of the first svRNA in SARS-CoV and its identified ortholog in SARS-CoV-2. Top: nsp3.1 svRNA sequence GAGGAAGAAGAGGACGAT in SARS-CoV according to [1].Bottom: Ortholog of nsp3.1 svRNA sequence GATGAAGAAGAAGGTGAT in SARS-CoV-2. | represents a match, − represents a gap (indel), empty represents a mismatch, and : represents anon-detrimental mismatch. GAGGAAGAAG−AAGAGGAAGACTGAAGAAG−AGCAAGAAGAAGATT
Figure 2: Alignment of the second svRNA in SARS-CoV and its identified ortholog in SARS-CoV-2. Top: nsp3.2 svRNA sequence GAGGAAGAAGAAGAGGAAGACT in SARS-CoV accordingto [1]. Bottom: Ortholog of nsp3.2 svRNA sequence GAAGAAGAGCAAGAAGAAGATT inSARS-CoV-2. | represents a match, − represents a gap (indel), empty represents a mismatch, and : represents a non-detrimental mismatch. AGGAACTGGCCCAGAAGCT−−TCAGGAACTGGGCCAGAAGCTGGAC
Figure 3: Alignment of the third svRNA in SARS-CoV and its identified ortholog in SARS-CoV-2.Top: N svRNA sequence AGGAACTGGCCCAGAAGCTTC in SARS-CoV according to [1].Bottom: Ortholog of N svRNA sequence AGGAACTGGGCCAGAAGCTGGAC in SARS-CoV-2. | represents a match, − represents a gap (indel), empty represents a mismatch, and dotted linerepresents a potential omission. It is possible that some or all of the last four (4) nucleotidesGGAC of the bottom sequence are dropped (omitted).4CBI ID svRNA1 svRNA2 svRNA31 LC528232 3056 3182 286152 LC528233 3061 3187 286203 LC529905 3053 3179 286124 LC529996 3033 3159 285925 LR757995 3038 3164 285976 LR757998 3028 3154 285877 MN908947 3053 3179 286128 MN938384 3021 3147 285809 MN975262 3053 3179 2861210 MN985325 3053 3179 2861211 MN988668 3052 3178 2861112 MN988669 3052 3178 2861113 MN988713 3053 3179 2861214 MN994467 3053 3179 2861215 MN994468 3053 3179 2861216 MN996527 3020 3146 2857917 MN996528 3053 3179 2861218 MN996529 3041 3167 2860019 MN996530 3039 3165 2859820 MN996531 3040 3166 2859921 MN997409 3053 3179 2861222 MT007544 3053 3179 2861223 MT012098 3040 3166 2859624 MT019529 3053 3179 2861225 MT019530 3053 3179 2861226 MT019531 3053 3179 2861227 MT019532 3053 3179 2861228 MT019533 3053 3179 2861229 MT020781 3053 3179 2861230 MT020880 3053 3179 2861231 MT020881 3053 3179 2861232 MT027062 3053 3179 2861233 MT027063 3053 3179 2861234 MT027064 3053 3179 2861235 MT039873 3050 3176 2860936 MT039887 3053 3179 2860937 MT039888 3053 3179 2861238 MT039890 3053 3179 2861239 MT044257 3053 3179 2861240 MT044258 3029 3155 2858841 MT049951 3053 3179 2861242 MT050493 3033 3159 2859243 MT066156 3053 3179 2861244 MT066175 3053 3179 2861245 MT066176 3053 3179 2861256 MT072688 3038 3164 2859747 MT093571 3053 3179 2861248 MT093631 3040 3166 2859949 MT106052 3053 3179 2861250 MT106053 3053 3179 2861251 MT106054 3053 3179 2861252 MT118835 3053 3179 2861253 MT121215 3053 3179 2861254 MT123290 3056 3182 2861555 MT123291 3050 3176 2860956 MT123292 3053 3179 2861257 MT123293 3047 3173 2860658 MT126808 3053 3179 2861259 MT135041 3053 3179 2861260 MT135042 3053 3179 2861261 MT135043 3053 3179 2861262 MT135044 3053 3179 2861263 MT152824 3051 3177 2861064 MT159705 3053 3179 2861265 MT159706 3053 3179 2861266 MT159707 3053 3179 2861267 MT159708 3053 3179 2861268 MT159709 3053 3179 2861269 MT159710 3053 3179 2861270 MT159711 3053 3179 2861271 MT159712 3053 3179 2861272 MT159713 3053 3179 2861273 MT159714 3053 3179 2861274 MT159715 3053 3179 2861275 MT159716 3038 3164 2859776 MT159717 3053 3179 2861277 MT159718 3053 3179 2861278 MT159719 3053 3179 2861279 MT159720 3053 3179 2861280 MT159721 3053 3179 2861281 MT159722 3053 3179 2861282 MT163716 3053 3179 2861283 MT163717 3047 3173 2860684 MT163718 3053 3179 2861285 MT163719 3053 3179 2861286 MT184907 3053 3179 2861287 MT184908 3053 3179 2861288 MT184909 3053 3179 2861289 MT184910 3053 3179 2861290 MT184911 3053 3179 2861291 MT184912 3053 3179 2861262 MT184913 3053 3179 2861293 MT188339 2999 3125 2855894 MT188340 2999 3125 2855895 MT188341 2999 3125 2856196 MT192759 3026 3152 2858597 MT192765 3046 3172 2860598 MT192772 3053 3179 2861299 MT192773 3052 3178 28611100 MT226610 3053 3179 28612101 MT233519 2999 3125 28558102 MT233520 2999 3125 28558103 MT233521 2999 3125 28558104 MT233522 2999 3125 28558105 MT233523 2999 3125 28558106 MT240479 3017 3143 28576107 MT246449 2979 3105 28538108 MT246450 3022 3148 28581109 MT246451 3008 3134 28567110 MT246452 3046 3172 28605111 MT246453 2979 3105 28538112 MT246454 3044 3170 28603113 MT246455 3008 3134 28567114 MT246456 2996 3122 28555115 MT246457 2997 3123 28553116 MT246458 2927 3053 28486117 MT246459 3047 3173 28606118 MT246460 3053 3179 28612119 MT246461 3021 3147 28580120 MT246462 3053 3179 28612121 MT246463 2927 3053 28486122 MT246464 3002 3128 28561123 MT246465 2931 3057 28490124 MT246466 3047 3173 28606125 MT246467 3050 3176 28609126 MT246468 2993 3119 28552127 MT246469 3019 3145 28578128 MT246470 3035 3161 28594129 MT246471 3021 3147 28580130 MT246472 2968 3094 28527131 MT246473 2979 3105 28535132 MT246474 3043 3169 28602133 MT246475 3033 3159 28592134 MT246476 3014 3140 28573135 MT246477 3022 3148 28581136 MT246478 3040 3166 28599137 MT246479 2979 3105 28538738 MT246480 3052 3178 28611139 MT246481 3021 3147 28580140 MT246482 2996 3122 28555141 MT246483 2927 3053 28486142 MT246484 3021 3147 28580143 MT246485 2925 3051 28484144 MT246486 3021 3147 28580145 MT246487 3037 3163 28596146 MT246488 3026 3152 28585147 MT246489 3003 3129 28562148 MT246490 2997 3123 28556149 MT251972 3016 3142 28575150 MT251973 3049 3175 28608151 MT251974 3002 3128 28561152 MT251975 3025 3151 28584153 MT251976 3051 3177 28610154 MT251977 2979 3105 28538155 MT251978 3051 3177 28610156 MT251979 3002 3128 28561157 MT251980 3002 3128 28558158 MT253696 2999 3125 28558159 MT253697 2999 3125 28558160 MT253698 2999 3125 28558161 MT253699 2999 3125 28558162 MT253700 2999 3125 28558163 MT253701 2999 3125 28558164 MT253702 2999 3125 28558165 MT253703 2999 3125 28558166 MT253704 2999 3125 28558167 MT253705 2999 3125 28558168 MT253706 2999 3125 28558169 MT253707 2999 3125 28558170 MT253708 2999 3125 28558171 MT253709 2999 3125 28558172 MT253710 2999 3125 28558173 MT327745 3049 3175 28608174 MT328032 3053 3179 28612175 MT334563 3052 3178 28611176 MT345880 3006 3132 28565177 MT350251 3037 3163 28596178 MT350266 3053 3179 28612179 MT350282 3053 3179 28612180 MT359866 3043 3169 28602181 MT370944 3013 3139 28572182 MT370968 2989 3115 28548183 MT370975 2998 3124 28557884 MT371019 2998 3124 28557185 MT371024 2981 3107 28540186 MT371034 3006 3132 28565187 MT371035 2998 3124 28557188 MT371036 2998 3124 28557189 MT371037 2989 3115 28548190 MT371048 3053 3179 28612191 MT371568 2929 3055 28488192 MT371572 2945 3071 28504193 MT372481 3048 3174 28607194 MT374112 3051 3177 28610195 MT375470 3021 3147 28580196 MT385448 3050 3176 28609197 MT394529 3042 3168 28601198 MT394864 2999 3125 28558199 MT396242 3028 3154 28587Table 1: Start loci of the three svRNAs in various strainsof SARS-CoV-2 genome. 9 .1 Potential targets We also analyzed the potential target genes of these svRNAs in human body. To this end, weconsidered more than 32,000 known RNAs that are transcribed in human body. We processedthe sequence of each of these RNAs and removed the intron regions of each. Finally, we alignedthe reverse complement of our svRNAs to all the exon sequences. A highly similar region to thereverse complement of an svRNA is highly complementary to the svRNA and hence suggests ahigh chance of interacting with that svRNA. Tables showing the results of that alignment for theregions that had an alignment score higher than . with these three svRNAs are available in theAppendix Tables 2, 3, and 4. To compute the score of the alignment, we used a reward of one(1) for a pair of matching nucleotides and a penalty of negative one (-1) for substitutions andinsertion/deletions (indels). In the end, the total score was divided by the length of each svRNAto normalize the scores. Our proposed svRNAs for SARS-CoV-2 are highly conserved versions of the svRNAs of SARS-CoV.Presence of these svRNAs in all the 200 reference sequences that we used to test our hypothesisincreases the possibility of correctness of our claim. Also, our proposed svRNAs occur at verysimilar loci in different reference sequences, and these loci are almost the same as the ones forthe original svRNAs reported for SARS-CoV. The fact that the two viruses are in the samesubgenus makes our hypothesis more plausible. However, still this hypothesis has to be verifiedexperimentally.As mentioned earlier, the complete tables showing the possible target RNAs of our proposedsvRNAs are available in the supplementary document. However, it is worth mentioning some ofthem. The second highest match to the reverse complement of the first svRNA is HIF3A transcriptwhich is a transcriptional regulator in adaptive response to low oxygen levels. Silencing this geneaffects the reaction of the body in response to hypoxia. The second best match with the reversecomplement of the second svRNA is MEX3B transcript which is a member of MEX3 translationalregulators. MEX3 are RNA-binding proteins that are evolutionarily conserved and their in vivo functions is yet to be fully characterized.
In this paper, we reported three potential svRNAs, which are orthologs of SARS-CoV svRNAs,in the SARS-CoV-2 genome. To validate our results, we confirmed the discovered orthologs arefully conserved in all the publicly available genomes of various strains of SARS-CoV-2; the loci atwhich the SARS-CoV-2 orthologs occur are close to the loci at which SARS-CoV svRNAs occur.Furthermore, our proposed svRNAs occur at very similar loci in different reference sequences, andthese loci are almost the same as the ones for the original svRNAs reported in SARS-CoV.We also reported potential targets for these svRNAs. We hypothesize that the discoveredorthologs play a role in pathogenesis of SARS-CoV-2, and therefore, antagomir-mediated inhibitionof these SARS-CoV-2 svRNAs inhibits COVID-19. This in silico discovery still needs to beconfirmed using in vitro and in vivo experiments.10 eferences [1] Lucía Morales, Juan Carlos Oliveros, Raúl Fernandez-Delgado, Benjamin Robert tenOever, Luis Enjuanes,and Isabel Sola. Sars-cov-encoded small rnas contribute to infection-associated lung pathology.
Cell host µbe , 21(3):344–355, 2017.[2] Hongzhou Lu, Charles W Stratton, and Yi-Wei Tang. Outbreak of pneumonia of unknown etiology in wuhanchina: the mystery and the miracle.
Journal of Medical Virology .[3] Roujian Lu, Xiang Zhao, Juan Li, Peihua Niu, Bo Yang, Honglong Wu, Wenling Wang, Hao Song, BaoyingHuang, Na Zhu, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications forvirus origins and receptor binding.
The Lancet , 395(10224):565–574, 2020.[4] Yushun Wan, Jian Shang, Rachel Graham, Ralph S Baric, and Fang Li. Receptor recognition by the novelcoronavirus from wuhan: an analysis based on decade-long structural studies of sars coronavirus.
Journal ofvirology , 94(7), 2020.[5] Jürgen Brosius. Waste not, want not–transcript excess in multicellular eukaryotes.
TRENDS in Genetics ,21(5):287–288, 2005.[6] Alexander F Palazzo and Eliza S Lee. Non-coding rna: what is functional and what is junk?
Frontiers ingenetics , 6:2, 2015.[7] Marc Robert Fabian, Nahum Sonenberg, and Witold Filipowicz. Regulation of mrna translation and stabilityby micrornas.
Annual review of biochemistry , 79:351–379, 2010.[8] David P Bartel. Micrornas: target recognition and regulatory functions. cell , 136(2):215–233, 2009.[9] Paul R Reich, Bernard G Forget, Sherman M Weissman, and James A Rose. Rna of low molecular weight inkb cells infected with adenovirus type 2.
Journal of molecular biology , 17(2):428–439, 1966.[10] Kazimierz T Tycowski, Yang Eric Guo, Nara Lee, Walter N Moss, Tenaya K Vallery, Mingyi Xie, and Joan ASteitz. Viral noncoding rnas: more surprises.
Genes & development , 29(6):567–584, 2015.[11] Poornima Parameswaran, Ella Sklan, Courtney Wilkins, Trever Burgon, Melanie A Samuel, Rui Lu, K MarkAnsel, Vigo Heissmeyer, Shirit Einav, William Jackson, et al. Six rna viruses and forty-one hosts: viral smallrnas and modulation of small rna repertoires in vertebrate and invertebrate systems.
PLoS pathogens , 6(2),2010.[12] Jasmine T Perez, Andrew Varble, Ravi Sachidanandam, Ivan Zlatev, Muthiah Manoharan, Adolfo García-Sastre, et al. Influenza a virus-generated small rnas regulate the switch from transcription to replication.
Proceedings of the National Academy of Sciences , 107(25):11525–11530, 2010.[13] Joan Steitz, Sumit Borah, Demian Cazalla, Victor Fok, Robin Lytle, Rachel Mitton-Fry, Kasandra Riley, andTasleem Samji. Noncoding rnps of viral origin.
Cold Spring Harbor perspectives in biology , 3(3):a005165, 2011.[14] Amiya K Banerjee. Transcription and replication of rhabdoviruses.
Microbiological reviews , 51(1):66, 1987.[15] Bryan R Cullen. Viral and cellular messenger rna targets of viral micrornas.
Nature , 457(7228):421–425, 2009.[16] Bryan R Cullen. Viruses and micrornas: Riscy interactions with serious consequences.
Genes & development ,25(18):1881–1894, 2011.[17] Benjamin R Tenoever. Rna viruses and the host microrna machinery.
Nature Reviews Microbiology , 11(3),2013.[18] David P Bartel. Micrornas: genomics, biogenesis, mechanism, and function. cell , 116(2):281–297, 2004.[19] Michael S Diamond. Mechanisms of evasion of the type i interferon antiviral response by flaviviruses.
Journalof interferon & cytokine research , 29(9):521–530, 2009.[20] Katell Bidet, Dhivya Dadlani, and Mariano A Garcia-Blanco. G3bp1, g3bp2 and caprin1 are required fortranslation of interferon stimulated mrnas and are targeted by a dengue virus non-coding rna.
PLoS pathogens ,10(7), 2014.
21] Anjeanette Roberts, Damon Deming, Christopher D Paddock, Aaron Cheng, Boyd Yount, Leatrice Vogel,Brian D Herman, Tim Sheahan, Mark Heise, Gillian L Genrich, et al. A mouse-adapted sars-coronaviruscauses disease and mortality in balb/c mice.
PLoS pathogens , 3(1), 2007.[22] Marta L DeDiego, Enrique Álvarez, Fernando Almazán, María Teresa Rejas, Elaine Lamirande, AnjeanetteRoberts, Wun-Ju Shieh, Sherif R Zaki, Kanta Subbarao, and Luis Enjuanes. A severe acute respiratorysyndrome coronavirus that lacks the e gene is attenuated in vitro and in vivo.
Journal of virology , 81(4):1701–1713, 2007.[23] Temple F Smith and Michael S Waterman. Comparison of biosequences.
Advances in Applied Mathematics ,2(4):482–489, 1981.[24] Saul B Needleman and Christian D Wunsch. A general method applicable to the search for similarities in theamino acid sequence of two proteins.
Journal of molecular biology , 48(3):443–453, 1970. ppendices Tables 2, 3, and 4 show the matches with a score of at least 70% between more than 32,000 RNAs transcribed inthe human body and reverse-complement of our propossed svRNAs for Sars-CoV-2. The ones with a high score arelikely to be target genes of the corresponding svRNA. The entries of each table are sorted based on the normalizedscore of the alignment.Tables 5, 6, and 7 show the matches with a score of at least 80% between our proposed svRNAs and humanreference genome. Patch release 13 of build 38 was used for as the reference genome. ene ID Score Matched Sequence Loci1 ENSG00000168421 0.94 ATCACCTTCTTCTTCACTC 20ATCACCTTCTTCTTCA-TC2 ENSG00000196218 0.89 ATCACCTTCTTCTTCTTC 15459ATCACCTTCTTCTTCATC3 ENSG00000124440 0.89 ATCACCTTCTTCTTCTTC 5383ATCACCTTCTTCTTCATC4 ENSG00000234545 0.83 ATTCATCTTCTTCTTCATC 1521A-TCACCTTCTTCTTCATC5 ENSG00000186867 0.83 ATCACCTTCTTCTGCATTC 692ATCACCTTCTTCTTCA-TC6 ENSG00000108100 0.83 ATCACCTTCTCTCTTCAAGTC 4064ATCACCTTCT-TCTTC-A-TC7 ENSG00000119632 0.83 ATTCACCTTCTTCTTC-TC 1524A-TCACCTTCTTCTTCATC8 ENSG00000168038 0.83 ATCACCTGTCTTCTGCATC 5803ATCACCT-TCTTCTTCATC9 ENSG00000229913 0.83 ATCACCTTCTGCTGTCATC 274ATCACCTTCTTCT-TCATC10 ENSG00000137767 0.78 ATCA-CTTCTTCTTCCCATC 315ATCACCTTCTTCTT–CATC11 ENSG00000135902 0.78 ATCACCTTCTACCTCATC 929ATCACCTTCTTCTTCATC12 ENSG00000136758 0.78 ATCAGCCTTC-TCTCTCATC 1553ATCA-CCTTCTTCT-TCATC13 ENSG00000250448 0.78 ATCACCTTCTTCTT-GTC 1192ATCACCTTCTTCTTCATC14 ENSG00000105675 0.78 ATCACCATCCTCTTCATC 2635ATCACCTTCTTCTTCATC15 ENSG00000013375 0.78 ATCACCTACTTCATCATC 6738ATCACCTTCTTCTTCATC16 ENSG00000151553 0.78 AGCACTTTCTTCTTCATC 3956ATCACCTTCTTCTTCATC17 ENSG00000157388 0.78 ATCTCCATCTTCTTCATC 5845ATCACCTTCTTCTTCATC18 ENSG00000173227 0.78 ATCACCTTCGTCTCTTC-TC 10806 TCACCTTC-T-TCTTCATC19 ENSG00000163485 0.78 ATGCCACCTTCTGCTTCATC 1300AT–CACCTTCTTCTTCATC20 ENSG00000103599 0.78 ATC-CCTTCTTCTTC-TC 5911ATCACCTTCTTCTTCATC21 ENSG00000148935 0.78 TTCACCTTCTCCTTCATC 2061ATCACCTTCTTCTTCATC22 ENSG00000106278 0.78 ATCGAACTTCTTCTATCATC 7929ATC-ACCTTCTTCT-TCATC23 ENSG00000115232 0.78 AT-ACCTTC-TCTTCATC 1025ATCACCTTCTTCTTCATC24 ENSG00000184083 0.78 ATCTACC-TCTTCTTCACTC 4572ATC-ACCTTCTTCTTCA-TC25 ENSG00000188687 0.78 ATCAGCTTCATCTTCATC 3941ATCACCTTCTTCTTCATC26 ENSG00000279010 0.78 ACCACCATTCTTCTCTCATC 4323ATCACC-TTCTTCT-TCATC27 ENSG00000188352 0.78 ATCACCGTCTTCTCCATC 188ATCACCTTCTTCTTCATC28 ENSG00000276460 0.78 AGCACCTTTTTCTTCATC 685ATCACCTTCTTCTTCATC29 ENSG00000100181 0.78 ATGACCTTCTTCTTCTTC 8513ATCACCTTCTTCTTCATC30 ENSG00000081148 0.78 ATCATCTACTTCTTCATC 3543ATCACCTTCTTCTTCATC31 ENSG00000173208 0.78 ATCACCTACTTATTCATC 4148ATCACCTTCTTCTTCATC32 ENSG00000116783 0.78 CTCACCTTCTTCTTCTTC 3911ATCACCTTCTTCTTCATC33 ENSG00000237654 0.78 ATCACCTTCTTAACTCCATC 1902ATCACCTTCTT–CTTCATC34 ENSG00000117834 0.78 AT-ACCTTCTTCTTC-TC 703ATCACCTTCTTCTTCATC35 ENSG00000198793 0.78 ATCACCTTCATCTTCAAGTC 3000ATCACCTTCTTCTTC-A-TC TCACCTTCTTCTTCATC54 ENSG00000114841 0.78 ATCACCTTCCTCTTC-TC 8495ATCACCTTCTTCTTCATC55 ENSG00000197077 0.78 ATCACCTTCTCTCTTCTTGC 5266ATCACCTTCT-TCTTCAT-C56 ENSG00000083544 0.78 ATCAGCCTTTCTTCTTTATC 5611ATCA-CC-TTCTTCTTCATC57 ENSG00000187533 0.78 ATCCACCTTCTTCCTT-ATC 4084AT-CACCTTCTT-CTTCATC58 ENSG00000147724 0.78 ATC-CCTGTCATTCTTCATC 719ATCACCT-TC-TTCTTCATC59 ENSG00000143126 0.78 CTCACCTTCTTCTTCCTC 7471ATCACCTTCTTCTTCATC60 ENSG00000185950 0.78 A-CAGCTTCTTCTTCATC 1270ATCACCTTCTTCTTCATC61 ENSG00000266885 0.78 CTCACCTTTTTCTTCATC 1963ATCACCTTCTTCTTCATC62 ENSG00000198796 0.78 ATCACCTGCTGTCTTCACTC 9006ATCACCTTCT-TCTTCA-TC63 ENSG00000081059 0.78 ACTCACCTCTGTTCTTCATC 3422A-TCACCT-TCTTCTTCATC64 ENSG00000091986 0.78 ATCACTTTCTTCGTTCATTC 5768ATCACCTTCTTC-TTCA-TC65 ENSG00000100142 0.78 ACCACCATTCTTCTCTCATC 68ATCACC-TTCTTCT-TCATC66 ENSG00000237921 0.78 ATCATCCTCTCTTCTTC-TC 272ATCA-CCT-TCTTCTTCATC67 ENSG00000074706 0.78 ATCACCTTCTTCTCCCTC 3106ATCACCTTCTTCTTCATC68 ENSG00000164418 0.78 ATCACCATCTTCATCATC 5587ATCACCTTCTTCTTCATC69 ENSG00000167216 0.78 ATCACCTTCTT-TTC-TC 4520ATCACCTTCTTCTTCATC70 ENSG00000257230 0.78 CTCACCTT-TTCTTCATC 214ATCACCTTCTTCTTCATC TCACC-TT-CTTCTTCATC89 ENSG00000251615 0.78 TTCACCTTCTTCTTC-TC 1388ATCACCTTCTTCTTCATC90 ENSG00000164185 0.78 ATCATCTTCTTGTTCATC 1070ATCACCTTCTTCTTCATC91 ENSG00000018280 0.78 A-CACCTTCTTCTTCCTC 3526ATCACCTTCTTCTTCATC92 ENSG00000176783 0.72 ATCACCTTCTGTCTCTCCA-C 4534ATCACCTTCT-TCT-T-CATC93 ENSG00000226145 0.72 AGCACCTTC-TCTTCACTC 32ATCACCTTCTTCTTCA-TC94 ENSG00000151413 0.72 ATGAACCTCTGCTTCTTCATC 6002AT-CACCT-T-CTTCTTCATC95 ENSG00000184014 0.72 ATCATC-TCTTCTTTCATC 7058ATCACCTTCTTC-TTCATC96 ENSG00000244242 0.72 ATCATCC-TCGTCTTCATC 1867ATCA-CCTTCTTCTTCATC97 ENSG00000279675 0.72 ATCCCCTTACTTCTTCAGC 3155ATCACCTT-CTTCTTCATC98 ENSG00000165424 0.72 TTGCACCTTCTTCTTCTTATC 4332AT-CACCTTCTTCTTC–ATC99 ENSG00000132640 0.72 CTCACCTTCTTCTTGATGC 936ATCACCTTCTTCTTCAT-C100 ENSG00000205086 0.72 ATTCACTCATTCATTCTTTCATC 87A-TCAC-C-TTC-TTC-TTCATC101 ENSG00000177058 0.72 CTCACCTTATTCTGTCATC 6939ATCACCTTCTTCT-TCATC102 ENSG00000238062 0.72 ATCAACCTCTCTCTCTTCCTC 2188ATC-ACCT-TCT-TCTTCATC103 ENSG00000135824 0.72 AGCACCTTCTTTCTTGATC 2871ATCACCTTC-TTCTTCATC104 ENSG00000261371 0.72 ATCACCCTC-TCATTCATC 1118ATCACCTTCTTC-TTCATC105 ENSG00000274333 0.72 ATCACCTT-TTGTTTCATC 6919ATCACCTTCTT-CTTCATC
06 ENSG00000248966 0.72 ATCACCTTCTTCTCCCAGTTC 2270ATCACCTTCTTCT-TCA–TC107 ENSG00000179218 0.72 CTCACCTTCTTCCTTCTTC 1032ATCACCTTCTT-CTTCATC108 ENSG00000123243 0.72 ATCACCTTTTTTCTTCCTC 12805ATCACC-TTCTTCTTCATC109 ENSG00000104321 0.72 A-CACCTTCTTCTTGCATT 396ATCACCTTCTTCTT-CATC110 ENSG00000100150 0.72 AGTC-CCTTCTTTTTCATC 6080A-TCACCTTCTTCTTCATC111 ENSG00000072041 0.72 AGCACCATTCTTCTTC-TC 8645ATCACC-TTCTTCTTCATC112 ENSG00000230894 0.72 AACACCGTTC-TCTTCATC 1223ATCACC-TTCTTCTTCATC113 ENSG00000086570 0.72 ATCAGACCCTTGACTTCTTCATC 7974ATC–A-CCTT–CTTCTTCATC114 ENSG00000162511 0.72 ATCACCATGCTCTTCATCATC 1334ATCACC-T–TCTTCTTCATC115 ENSG00000099977 0.72 ATAATCC-TCTTCTTCATC 1693ATCA-CCTTCTTCTTCATC116 ENSG00000270104 0.72 ATCTACCTATCTTCCTGTCTATC 475ATC-ACCT-TCTT-CT-TC-ATC117 ENSG00000153822 0.72 A-CACCTTCTTCTTTCTTC 2169ATCACCTTCTTC-TTCATC118 ENSG00000236449 0.72 ATCACCATCTTCTCCACTC 1202ATCACCTTCTTCTTCA-TC119 ENSG00000278903 0.72 ATCACCTT-TTGTTTCATC 1826ATCACCTTCTT-CTTCATC120 ENSG00000173705 0.72 ATCGCC-TCTTCCTTCATC 2591ATCACCTTCTT-CTTCATC121 ENSG00000172215 0.72 AACACCTGCTCTTCTTCATAC 670ATCACCT–TCTTCTTCAT-C122 ENSG00000055609 0.72 ATC-CCTACTTCTTCAGTC 19286ATCACCTTCTTCTTCA-TC123 ENSG00000139174 0.72 ATCTCCTTTCCATTCTTCATC 7102 TCACC-TT-C-TTCTTCATC124 ENSG00000178607 0.72 ATCAACCTCTCTTCTGT-ATC 2866ATC-ACCT-TCTTCT-TCATC125 ENSG00000109163 0.72 ATCA-CTTCTTCTTTC-TC 939ATCACCTTCTTC-TTCATC126 ENSG00000179912 0.72 ATCACTCTTCTTC-CCATC 5117ATCAC-CTTCTTCTTCATC127 ENSG00000250220 0.72 ATC-CCTTCTATGTTCATC 592ATCACCTTCT-TCTTCATC128 ENSG00000279128 0.72 ATC-CGTTCTGTCTTCATC 685ATCACCTTCT-TCTTCATC129 ENSG00000088726 0.72 ATCCTCCTCATCTTCTTCATC 741AT-CACCT–TCTTCTTCATC130 ENSG00000047579 0.72 AGCCACCTTCTTCTTCCTC 2703A-TCACCTTCTTCTTCATC131 ENSG00000183908 0.72 ATCATCGTGGTCTTCTTCATC 2729ATCA-CCT–TCTTCTTCATC132 ENSG00000035862 0.72 ATCACCCTCTGTGACTTCATC 1092ATCACCTTCT-T–CTTCATC133 ENSG00000133247 0.72 ATCTACCTCTCTTCTCTC-TC 2098ATC-ACCT-TCTTCT-TCATC134 ENSG00000154065 0.72 AGTCACCTGTCTCTCTCATCATC 1881A-TCACCT-TCT-TCT–TCATC135 ENSG00000254541 0.72 AACACCTTCTCTCTCTACATC 184ATCACCTTCT-TCT-T-CATC136 ENSG00000157765 0.72 ATCATCTTCTTCTTCCTGATC 2227ATCACCTTCTTCTT-C–ATC137 ENSG00000143669 0.72 ATC-CCTTCTACTTCAGTC 2947ATCACCTTCTTCTTCA-TC138 ENSG00000179841 0.72 ATCAGCTTGCTT-TTCATC 792ATCACCTT-CTTCTTCATC139 ENSG00000213760 0.72 ATC-CCTGTCTTCTTTCCATC 1280ATCACCT-TCTTC-TT-CATC140 ENSG00000137210 0.72 A-CACTTTCTTCTATCATC 3948ATCACCTTCTTCT-TCATC
41 ENSG00000065135 0.72 ATCACCTTTGTTCTTCAGC 18023ATCACC-TTCTTCTTCATC142 ENSG00000181847 0.72 ATCTACCTT-TTCTGCATC 4887ATC-ACCTTCTTCTTCATC143 ENSG00000250383 0.72 ATCCATCTTCTTCTCTCCATC 92AT-CACCTTCTTCT-T-CATC144 ENSG00000197852 0.72 TTCACCCATTCTTCTTCAGTC 1541ATCA-CC-TTCTTCTTCA-TC145 ENSG00000170374 0.72 CTCACCTTCTCTCTTCACC 2017ATCACCTTCT-TCTTCATC146 ENSG00000106344 0.72 ATC-CACTCTCTTCTTCATTC 3649ATCAC-CT-TCTTCTTCA-TC147 ENSG00000185811 0.72 ACTCACACTTCTTCTTTCTCATC 1068A-TCAC-CTTCTTC–T-TCATC148 ENSG00000130649 0.72 AGTCATCCTTCTTCTT-ACTC 9269A-TCA-CCTTCTTCTTCA-TC149 ENSG00000196935 0.72 ATTCAGCCTTCTATCTGGTCATC 9731A-TCA-CCTTCT-TCT–TCATC150 ENSG00000009765 0.72 ATCACCTTCTGTCGTCCTC 3864ATCACCTTCT-TCTTCATC151 ENSG00000260073 0.72 ATCA-CTTCTGTCTT-ATC 2178ATCACCTTCT-TCTTCATC152 ENSG00000249915 0.72 ATGCACCTTTTTCCTCATC 1147AT-CACCTTCTTCTTCATC153 ENSG00000170275 0.72 A-CACCTGTCTTCTT-ATC 1890ATCACCT-TCTTCTTCATC154 ENSG00000145348 0.72 ATCACCTGTCTTCTGCGTC 4475ATCACCT-TCTTCTTCATC155 ENSG00000165629 0.72 TTCTACCTTTGCTTCTTCATC 1436ATC-ACC-TT-CTTCTTCATC156 ENSG00000281357 0.72 ATCACTTTCCTTCTTCCTC 184ATCACCTT-CTTCTTCATC157 ENSG00000117472 0.72 ACTCA-GTTCTTCTTCATC 1398A-TCACCTTCTTCTTCATC158 ENSG00000099341 0.72 A-CACCTTCTTCATTGACATC 1453 TCACCTTCTTC-TT–CATC159 ENSG00000213853 0.72 ATCCACCATTCATTCATTCATTC 5343AT-CACC-TTC-TTC-TTCA-TC160 ENSG00000148600 0.72 ATCATCC-TCTTCCTCATC 3955ATCA-CCTTCTTCTTCATC161 ENSG00000280548 0.72 ATCACCTATCTTCCTCTCA-C 2047ATCACCT-TCTT-CT-TCATC162 ENSG00000258754 0.72 ACCACCTTCGTTCCCTTCATC 2201ATCACCTTC-TT–CTTCATC163 ENSG00000125538 0.72 AGCACCTTCTTTCCCTTCATC 1330ATCACCTTC-TT–CTTCATC164 ENSG00000235100 0.72 AT-ACCTTCTTACTT-ATC 463ATCACCTTCTT-CTTCATC165 ENSG00000184154 0.72 ATCATCC-TCTTCTTCCTC 5558ATCA-CCTTCTTCTTCATC166 ENSG00000267767 0.72 ATCCACATTTCTTCTCTCATC 2191AT-CAC-CTTCTTCT-TCATC167 ENSG00000276077 0.72 ATCACCTT-TTGTTTCATC 1680ATCACCTTCTT-CTTCATC168 ENSG00000280156 0.72 TTCACCTTCTTCATTCACCTC 78199ATCACCTTCTTC-TTCA–TC169 ENSG00000175697 0.72 A-CAGCTTCTTCTATCATC 5324ATCACCTTCTTCT-TCATC170 ENSG00000259485 0.72 ATCACCTGTCTTCTGCGTCACTC 363ATCACCT-TCTTCT—TCA-TC171 ENSG00000129467 0.72 ATCACCTTCCTCCTCTTCCTC 4859ATCACCTT-CT–TCTTCATC172 ENSG00000246022 0.72 ATCA-CTTCATTCTT-ATC 2118ATCACCTTC-TTCTTCATC173 ENSG00000158528 0.72 ATC-CCTCCTCTTCTTCAATC 4429ATCACCT–TCTTCTTC-ATC174 ENSG00000197157 0.72 ATCACCTTCTTGCTTGCAGTT 3279ATCACCTTCTT-CTT-CA-TC175 ENSG00000139219 0.72 ATTCTTACCTTCTTCTTC-TC 1599A-TC–ACCTTCTTCTTCATC
76 ENSG00000153395 0.72 ATCACCTGTCTTGCTTTCCCATC 1211ATCACCT-TCTT-C-TT–CATC177 ENSG00000140943 0.72 ATCAACCTCTCTGTCTTCTTC 8498ATC-ACCT-TCT-TCTTCATC178 ENSG00000213676 0.72 TTCACCTCTCTTC-TCATC 3305ATCACCT-TCTTCTTCATC179 ENSG00000087460 0.72 ATC-CCTTCTTCTTGC-TC 155ATCACCTTCTTCTT-CATC180 ENSG00000204160 0.72 ATC-CTCTTCTTCTTCGTC 552ATCAC-CTTCTTCTTCATC181 ENSG00000279006 0.72 ATCACCTT-TGTCTTCA-C 1031ATCACCTTCT-TCTTCATC182 ENSG00000235824 0.72 ATAACATTCTTCTTCATGC 38ATCACCTTCTTCTTCAT-C183 ENSG00000185272 0.72 ATTA-CTTCTTCTTTCATC 720ATCACCTTCTTC-TTCATC184 ENSG00000134444 0.72 ATGCCACCTTCTTC-TCTATC 1818AT–CACCTTCTTCTTC-ATC185 ENSG00000196083 0.72 ATCACCTGCTTCTATCAGC 206ATCACCTTCTTCT-TCATC186 ENSG00000149972 0.72 ATCAACTTCTTACTTACACTC 8455ATCACCTTCTT-CTT-CA-TC187 ENSG00000161999 0.72 ACTCACCTTCCTCTTCTCATC 2216A-TCACCTTCTTC-T-TCATC188 ENSG00000144596 0.72 ATTC-CCTGCTTCTTCATC 3428A-TCACCTTCTTCTTCATC189 ENSG00000134243 0.72 ACTCACTCTTCTTTCTTC-TC 7525A-TCAC-CTTC-TTCTTCATC190 ENSG00000007312 0.72 ATCATCC-TCTTCATCATC 1409ATCA-CCTTCTTCTTCATC191 ENSG00000235750 0.72 ATCACAC-TCCTCTTCATC 877ATCAC-CTTCTTCTTCATC192 ENSG00000112394 0.72 ATTACCTTCTTTTTACATC 6666ATCACCTTCTTCTT-CATC193 ENSG00000143294 0.72 ATCACATATCTTATTCATC 3644 TCACCT-TCTTCTTCATC194 ENSG00000105202 0.72 ATCACCTATCTTCCTCTCA-C 2047ATCACCT-TCTT-CT-TCATC195 ENSG00000115183 0.72 AGCACCGTTCTTC-TCATC 2647ATCACC-TTCTTCTTCATC196 ENSG00000188283 0.72 ATCATTCCTTTCTTCTTCAGCTC 684ATCA–CC-TTCTTCTTCA–TC197 ENSG00000226312 0.72 ATTCTACCATCTTCTTCCATC 886A-TC-ACCTTCTTCTT-CATC198 ENSG00000091536 0.72 CTCCTCCTTCTTCTTCATC 17565AT-CACCTTCTTCTTCATC199 ENSG00000154265 0.72 AT-ACCTT-TTCCTTCATC 10718ATCACCTTCTT-CTTCATC200 ENSG00000147118 0.72 ATTCAGCCTTTCTTCTTTTCATC 2376A-TCA-CC-TTCTTC–TTCATC201 ENSG00000232021 0.72 ATCAACACTTCCTTCTACATC 402ATC-AC-CTT-CTTCTTCATC202 ENSG00000169087 0.72 ATCACACTTCTTC–CATC 3353ATCAC-CTTCTTCTTCATC203 ENSG00000154237 0.72 A-CAGCCTTCTTC-TCATC 5809ATCA-CCTTCTTCTTCATC204 ENSG00000132182 0.72 ATC-CCTCCTTCTTACATC 645ATCACCTTCTTCTT-CATC205 ENSG00000260880 0.72 ATC-CCTTCATTCTTCAGC 640ATCACCTTC-TTCTTCATC206 ENSG00000153347 0.72 AGTCATCTTCTTTTTCATC 2332A-TCACCTTCTTCTTCATC207 ENSG00000044446 0.72 ATCAGCCTTTTTCTTCACC 6802ATCA-CCTTCTTCTTCATC208 ENSG00000177663 0.72 ATCACCTTATT-TTACATC 8539ATCACCTTCTTCTT-CATC209 ENSG00000144029 0.72 ATCACCTGTCTTCTGCGTCAGTC 3912ATCACCT-TCTTCT—TCA-TC210 ENSG00000131591 0.72 CTCACCTGCTGTCTTCATC 1166ATCACCTTCT-TCTTCATC
11 ENSG00000116641 0.72 ATCACCTTCTGT-TTCTTC 8041ATCACCTTCT-TCTTCATC212 ENSG00000282961 0.72 ATCACCATGTCTATC-TCATC 4883ATCACC-T-TCT-TCTTCATC213 ENSG00000277991 0.72 ATCACCTT-TTGTTTCATC 6070ATCACCTTCTT-CTTCATC214 ENSG00000231049 0.72 ACTCTCCTTTCTTCTTCACTC 3182A-TCACC-TTCTTCTTCA-TC215 ENSG00000130038 0.72 AGTCA-CTTCTTCTTCAGC 8197A-TCACCTTCTTCTTCATC216 ENSG00000259134 0.72 ATCAGCTATCTTCTGTCTATC 1611ATCACCT-TCTTCT-TC-ATC217 ENSG00000253894 0.72 ATC-CCTTCATTCTTCTTC 3095ATCACCTTC-TTCTTCATC218 ENSG00000174255 0.72 ATCA-C-TCTGTCTTCATC 935ATCACCTTCT-TCTTCATC219 ENSG00000088387 0.72 ATCATAGCCTTGCTGTCTTCATC 4404ATC–A-CCTT-CT-TCTTCATC220 ENSG00000162804 0.72 AT-ACCTTCTATCTTGCCATC 8563ATCACCTTCT-TCTT–CATC221 ENSG00000080815 0.72 ATCACCTTCTTC-CCATAC 2244ATCACCTTCTTCTTCAT-C222 ENSG00000109182 0.72 ATCACCTTCTTCCGTCACC 2397ATCACCTTCTT-CTTCATC223 ENSG00000143322 0.72 AGTGCA-CTTACTTCTTCATC 11625A-T-CACCTT-CTTCTTCATC224 ENSG00000152705 0.72 ATTCACCATCATCTTCATC 1038A-TCACCTTCTTCTTCATC225 ENSG00000242715 0.72 ATTCCTACCTT-TTCTTCATC 6826A-T-C-ACCTTCTTCTTCATC226 ENSG00000186847 0.72 AGCACCTTC-TCTTCACTC 32ATCACCTTCTTCTTCA-TC227 ENSG00000035499 0.72 ATCACCTTTCTTTTCTTTATC 1019ATCACC-TTC–TTCTTCATC228 ENSG00000245937 0.72 ATCACCTTCCCACTTCATC 4885 TCACCTT-CTTCTTCATC229 ENSG00000227110 0.72 ATCACCCGTCTTCTGCATC 104ATCA-CCTTCTTCTTCATC230 ENSG00000165181 0.72 ATCACCTTCCTCTTCAATA 2832ATCACCTTCTTCTTC-ATC231 ENSG00000188984 0.72 ATGCCACCTTCTCCTCTTCATAC 2325AT–CACCTTCT–TCTTCAT-C232 ENSG00000126777 0.72 ATTACCTTCTTCCTTCATGGC 7317ATCACCTTCTT-CTTCAT–C233 ENSG00000155886 0.72 ATCGTCCTTC-TCTTCATC 1881ATC-ACCTTCTTCTTCATC234 ENSG00000254465 0.72 ACTCACACTTCTTTTCTATCATC 763A-TCAC-CTTC–TTCT-TCATC235 ENSG00000175841 0.72 ATCACCATTCTGCTCTTCTTATC 308ATCACC-TTCT–TCTTC–ATC236 ENSG00000112096 0.72 ATCACCTGTCTTCTGCGTC 17359ATCACCT-TCTTCTTCATC237 ENSG00000255085 0.72 ATCACCCATTCTTTCTTC-TC 496ATCA-CC-TTC-TTCTTCATC238 ENSG00000259711 0.72 AGTCACCGTCTTCTTC-TC 1A-TCACCTTCTTCTTCATC239 ENSG00000143515 0.72 ATCAACC-ACTTCTTCATC 4865ATC-ACCTTCTTCTTCATC240 ENSG00000174151 0.72 ATC-CCTTCTT-TCTCATC 4001ATCACCTTCTTCT-TCATC241 ENSG00000157680 0.72 ATCA-CTTCATT-TTCATC 8636ATCACCTTC-TTCTTCATC242 ENSG00000081014 0.72 ACTCTCCTT-TTCTTCATC 2696A-TCACCTTCTTCTTCATC243 ENSG00000169679 0.72 ATCATCTCTTCTT-TGTCATC 3299ATCA-C-CTTCTTCT-TCATC244 ENSG00000101096 0.72 ATCACCTTTTTCTTGC-TC 6883ATCACCTTCTTCTT-CATC245 ENSG00000280145 0.72 ATCACCTT-TTGTTTCATC 7385ATCACCTTCTT-CTTCATC
46 ENSG00000111481 0.72 AT-ACCTCTTCTCTCTTCATC 2300ATCA-C-CTTCT-TCTTCATC247 ENSG00000152061 0.72 ATCACCTGTCTTCTGCGTC 5636ATCACCT-TCTTCTTCATC248 ENSG00000154783 0.72 ACTCCCCTTCTTCTTCCTC 5441A-TCACCTTCTTCTTCATC249 ENSG00000235522 0.72 AT-AACTTCTTCTGTCATC 957ATCACCTTCTTCT-TCATC250 ENSG00000174844 0.72 AT-A-CTTCTTCTTCGATC 5219ATCACCTTCTTCTTC-ATC251 ENSG00000153046 0.72 ATCACCTGTCTTCTGCGTC 1044ATCACCT-TCTTCTTCATC252 ENSG00000234072 0.72 ATCACCTGCCCTTCTTCAGTC 85ATCACCT–TCTTCTTCA-TC253 ENSG00000136854 0.72 ATCATCCTTC-TCTACATC 4554ATCA-CCTTCTTCTTCATC254 ENSG00000153551 0.72 ATC-CCTTCTACTTCACTC 2498ATCACCTTCTTCTTCA-TC255 ENSG00000136449 0.72 ATTTACCTTCTTCTTCAAGTC 4528A-TCACCTTCTTCTTC-A-TC256 ENSG00000231918 0.72 ATC-CCTTCTTCCTTCCTC 1348ATCACCTTCTT-CTTCATC257 ENSG00000164587 0.72 ACTCCAGCCTTCTCTCCTTCATC 3505A-T-CA-CCTTCT-T-CTTCATC258 ENSG00000127507 0.72 CTCACC-TCTTCTTCCATC 4355ATCACCTTCTTCTT-CATC259 ENSG00000253355 0.72 ATCCACCTTGCTT-TTCCATC 261AT-CACCTT-CTTCTT-CATC260 ENSG00000174197 0.72 ATCTCCTGTCTTCTTTATC 13302ATCACCT-TCTTCTTCATC261 ENSG00000116095 0.72 ATC-CC-TCTATCTTCATC 6474ATCACCTTCT-TCTTCATC262 ENSG00000179604 0.72 AACAGCCCTCTTCTTCATC 2330ATCA-CCTTCTTCTTCATC263 ENSG00000024862 0.72 AT-ACCCTTCTTCTTCAGGTC 378 TCA-CCTTCTTCTTCA–TC264 ENSG00000198569 0.72 ATC-CACTTCTTCTTCAAC 1710ATCAC-CTTCTTCTTCATC265 ENSG00000144792 0.72 ATCACACTTCTCTCTTAACTC 3422ATCAC-CTTCT-TCTTCA-TC266 ENSG00000091262 0.72 ATCTACC-TCCTCTTCATC 236ATC-ACCTTCTTCTTCATC267 ENSG00000149948 0.72 ATCACCTTCTT-TGTAATC 12587ATCACCTTCTTCT-TCATC268 ENSG00000170180 0.72 TTCAACTTCTTCTTCAGTC 1575ATCACCTTCTTCTTCA-TC269 ENSG00000160588 0.72 ATCATTTTCCTTCTTCATC 3133ATCACCTT-CTTCTTCATC270 ENSG00000171827 0.72 ATC-CCTTAC-TCTTCATC 1909ATCACCTT-CTTCTTCATC271 ENSG00000197641 0.72 ATCATCCCTTCCTGTTCTTCATC 1923ATCA–CCTT-C–TTCTTCATC272 ENSG00000144152 0.72 ATCACCATTCATTCTTCTTTC 4646ATCACC-TTC-TTCTTC-ATC273 ENSG00000138778 0.72 AT-ACCTTCTTCTTGCATA 9217ATCACCTTCTTCTT-CATC274 ENSG00000198246 0.72 GTCACCTACGTCTTCTTCATC 1413ATCACCT—TCTTCTTCATC275 ENSG00000224885 0.72 ATCATCTTTTTCATTCATC 474ATCACCTTCTTC-TTCATC276 ENSG00000168671 0.72 ATCCACCTTCCTTC-TCATGC 2328AT-CACCTT-CTTCTTCAT-C277 ENSG00000127920 0.72 ATCACCTGCTTCTTTCATG 2544ATCACCTTCTTC-TTCATC278 ENSG00000102053 0.72 ACCACCTATCTCCTTCATC 91ATCACCT-TCTTCTTCATC279 ENSG00000154122 0.72 ATCACC-TCATTCTTCATTTC 10325ATCACCTTC-TTCTTCA–TC280 ENSG00000115419 0.72 ATTCACACTTCTTCCTTCTTC 5668A-TCAC-CTTCTT-CTTCATC
81 ENSG00000105722 0.72 ATC-CTCTTCTTCTTCTTC 1853ATCAC-CTTCTTCTTCATC282 ENSG00000135636 0.72 ATCATCC-TCTTCATCATC 8006ATCA-CCTTCTTCTTCATC283 ENSG00000267784 0.72 ATCA-CTTCTTCCTTC-TC 2064ATCACCTTCTT-CTTCATC284 ENSG00000099958 0.72 ATTCAGCTTCTTCTTCAAC 536A-TCACCTTCTTCTTCATC285 ENSG00000080644 0.72 AT-ACCTTGCTTCTTCACC 4287ATCACCTT-CTTCTTCATC286 ENSG00000135966 0.72 ATACACCCTC-TCTTCATC 4443AT-CACCTTCTTCTTCATC287 ENSG00000147874 0.72 ATCACCTTTTTCTTTATGC 7807ATCACCTTCTTCTTCAT-C288 ENSG00000215182 0.72 CTCAACCTTCTTCATCATC 1637ATC-ACCTTCTTCTTCATC289 ENSG00000140092 0.72 ATCAGCC-TCTTCTTCTTC 1294ATCA-CCTTCTTCTTCATC290 ENSG00000187555 0.72 ATCACTCTTATTTTTCATC 7155ATCAC-CTTCTTCTTCATC291 ENSG00000103335 0.72 ATCATCC-TCTTCCTCATC 9423ATCA-CCTTCTTCTTCATC292 ENSG00000170836 0.72 ATTC-CCTTCTTTTTCATC 3027A-TCACCTTCTTCTTCATC293 ENSG00000188649 0.72 AT-ACTCTTCTTCTTCACC 70ATCAC-CTTCTTCTTCATC294 ENSG00000141837 0.72 ATCGCCATGCTCTTCTTCATC 33937ATCACC-T–TCTTCTTCATC295 ENSG00000205730 0.72 ATCACCTTCTCGCTTCA-C 2027ATCACCTTCT-TCTTCATC296 ENSG00000184277 0.72 AGTCACCTTCTT-TTC-TC 8527A-TCACCTTCTTCTTCATC297 ENSG00000204697 0.72 ATCA-CTTCTTC-TCATTC 636ATCACCTTCTTCTTCA-TC298 ENSG00000112137 0.72 ACCACCTT-TTCTTCCATC 6578 TCACCTTCTTCTT-CATC299 ENSG00000169083 0.72 ATCACATGCTTC-TCTTCATC 4499ATCAC—CTTCTTCTTCATC300 ENSG00000198093 0.72 ATCTTCCCATTCTTCTTCATC 1594ATC–ACC-TTCTTCTTCATC301 ENSG00000280224 0.72 ATCACCATCATCTATCATC 883ATCACCTTCTTCT-TCATC302 ENSG00000099998 0.72 ATTCACCTT-TTCATTCATTC 1645A-TCACCTTCTTC-TTCA-TC303 ENSG00000172269 0.72 ATCATCCTCTTCTGCTTCATC 2459ATCA–C-CTTCTTCTTCATC304 ENSG00000275079 0.72 ATCACCTGTCTTGCTTTCCCATC 809ATCACCT-TCTT-C-TT–CATC305 ENSG00000171105 0.72 ATCACTTTCTCTCTGCATC 9192ATCACCTTCT-TCTTCATC306 ENSG00000131732 0.72 ATCACTCTT-TTCTTCCTC 1923ATCAC-CTTCTTCTTCATC307 ENSG00000171094 0.72 ATCACGCTTCTTCTCCA-C 2844ATCAC-CTTCTTCTTCATC308 ENSG00000072657 0.72 ATCTTCCTTTCATTCTTCATC 3711ATC-ACC-TTC-TTCTTCATC309 ENSG00000248905 0.72 ATCACCGTT-TTCTTCTTC 169ATCACC-TTCTTCTTCATC310 ENSG00000162337 0.72 ATCATCCTCTCTCTCTTCGTC 4960ATCA-CCT-TCT-TCTTCATC311 ENSG00000108387 0.72 ATGCACCTTC-TCTTC-TC 2142AT-CACCTTCTTCTTCATC312 ENSG00000088808 0.72 ATGATCCTTCTTCCCTTCATC 8092ATCA-CCTTCTT–CTTCATC313 ENSG00000123643 0.72 ATCA-CTTCTTCTTCAGTA 3610ATCACCTTCTTCTTCA-TC314 ENSG00000117408 0.72 ATCCACCCCTTC-TCTTCATC 4760AT-CA–CCTTCTTCTTCATC315 ENSG00000165970 0.72 ATCACTCTCTCTTCTTACAAC 1729ATCAC-CT-TCTTCTT-CATC
16 ENSG00000205060 0.72 ATCACCTTTTCCTTCTTCAGC 2028ATCACC–TT-CTTCTTCATC317 ENSG00000172671 0.72 A-CAGCCTTCTTCTTC-TC 4096ATCA-CCTTCTTCTTCATC318 ENSG00000274286 0.72 ATCACCTTCCTCATTC-TC 151ATCACCTTCTTC-TTCATC319 ENSG00000101337 0.72 ATCGAGC-TCTTCTTCATC 2186ATC-ACCTTCTTCTTCATC320 ENSG00000105409 0.72 ATCACCTTCTT-TTCCACC 1654ATCACCTTCTTCTT-CATC321 ENSG00000029363 0.72 ATCACCTTCTTCTCCCAGTTC 4555ATCACCTTCTTCT-TCA–TC322 ENSG00000160716 0.72 ATCCATCCTT-TTGCTTCATC 1909AT-CA-CCTTCTT-CTTCATC323 ENSG00000113073 0.72 ATCAGCC-TCATCTTCATC 1638ATCA-CCTTCTTCTTCATC324 ENSG00000154727 0.72 ATGCACCTTCTCCTTCATT 3569AT-CACCTTCTTCTTCATC325 ENSG00000080189 0.72 AT-ACCTTCATCTTCACTC 5934ATCACCTTCTTCTTCA-TC326 ENSG00000242550 0.72 ATCACCCATTCCTCTTCTTCATC 1755ATCA-CC–T–TCTTCTTCATC327 ENSG00000103222 0.72 AGTCACCTT-TTCTTC-TC 3333A-TCACCTTCTTCTTCATC328 ENSG00000146005 0.72 ATC-CACTTCTT-TTCATC 3102ATCAC-CTTCTTCTTCATC329 ENSG00000001626 0.72 CTCAGCCTTCTTCTTC-TC 1494ATCA-CCTTCTTCTTCATC330 ENSG00000182021 0.72 CTCACCTTCTTGCTTCTTC 1782ATCACCTTCTT-CTTCATC331 ENSG00000197893 0.72 A-CACCTTCTTCTTTC-TC 1988ATCACCTTCTTC-TTCATC332 ENSG00000177932 0.72 ATCATCCCTTCTT-TCTCATC 1074ATCA–CCTTCTTCT-TCATC333 ENSG00000123307 0.72 ATCACC-TCTTTTCTCATC 1520 TCACCTTCTTCT-TCATC334 ENSG00000212743 0.72 ACCACCTTC-TCTTCCATC 37ATCACCTTCTTCTT-CATC335 ENSG00000196923 0.72 ACTCACCTTC-TCTTC-TC 408A-TCACCTTCTTCTTCATC336 ENSG00000179630 0.72 ATCA-CTTCTTCTTTGATC 1313ATCACCTTCTTC-TTCATC337 ENSG00000111012 0.72 ATCACCCT-TTCATTCATC 2656ATCACCTTCTTC-TTCATC338 ENSG00000132915 0.72 ATCAACCTTCCTTCATTC-TC 6001ATC-ACCTT-CTTC-TTCATC339 ENSG00000185958 0.72 ATCACCATCTTCTCTCACTAC 6273ATCACCTTCTTCT-TCA-T-C340 ENSG00000258943 0.72 ATCAACCCTTATTCTGTCATC 827ATC-A-CCTTCTTCT-TCATC341 ENSG00000123066 0.72 ACTCAACCTTCTGTTACTTCATC 13350A-TC-ACCTTC–TT-CTTCATC342 ENSG00000166206 0.72 ATCTATCCATT-TTCTTCATC 5564ATC-A-CC-TTCTTCTTCATC343 ENSG00000073803 0.72 AT-ACCCTTC-TCTTCATC 4962ATCA-CCTTCTTCTTCATC344 ENSG00000100395 0.72 ATCACCTGCTTGGCTTCACTC 1323ATCACCTTCTT–CTTCA-TC345 ENSG00000118777 0.72 ACCACCTCCTTCTGTCATC 2018ATCACCTTCTTCT-TCATC346 ENSG00000100379 0.72 ATCCACC-TCTTCTTCCTC 1613AT-CACCTTCTTCTTCATC347 ENSG00000066322 0.72 ATGGCACCATCTTCTTCATGC 1864AT–CACCTTCTTCTTCAT-C348 ENSG00000134909 0.72 ATCAGCCTCCTTCTT-ATC 5069ATCA-CCTTCTTCTTCATC349 ENSG00000061676 0.72 ATCACCTTCTTC-TCAGTAAC 20776ATCACCTTCTTCTTCA-T–C350 ENSG00000280162 0.72 ATC-CCTTCTTGTCTGTCATC 744ATCACCTTC-T-TCT-TCATC
51 ENSG00000101204 0.72 ATCACCTATGCCTTCGTCATC 6151ATCACCT-T–CTTCTTCATC352 ENSG00000116299 0.72 ATTACCTTCTTCTTTCTTC 7668ATCACCTTCTTC-TTCATC353 ENSG00000165240 0.72 ATCACTCTTCTGTATTCACTC 7521ATCAC-CTTCT-TCTTCA-TC354 ENSG00000221813 0.72 ATCACCATGTCTACTTCAATC 1443ATCACC-T-TCTTCTTC-ATC355 ENSG00000279800 0.72 ATCACCTTCTTCTCCCAGTTC 2261ATCACCTTCTTCT-TCA–TC356 ENSG00000106692 0.72 ATCA-CTT-TTCTTTCATC 4521ATCACCTTCTTC-TTCATC357 ENSG00000153317 0.72 CTCACCTTCTTATTTCATC 4411ATCACCTTCTT-CTTCATC358 ENSG00000114251 0.72 ATCCACCTTCCTCTTCA-C 4029AT-CACCTTCTTCTTCATC359 ENSG00000130939 0.72 ATCATCTGTCTTCTTGATC 1546ATCACCT-TCTTCTTCATC360 ENSG00000146278 0.72 ATTCACCTTCTCCTTC-TC 94A-TCACCTTCTTCTTCATC361 ENSG00000116871 0.72 ATCATCTTCTTCATCGTCATC 1165ATCACCTTCTTC-T–TCATC362 ENSG00000198440 0.72 ATC-CCTTAC-TCTTCATC 1772ATCACCTT-CTTCTTCATC363 ENSG00000172493 0.72 AGTCATCTTCATCTTCATC 4117A-TCACCTTCTTCTTCATC364 ENSG00000076108 0.72 ATCACCTATTCTTTTTTCATC 2753ATCACC–TTC-TTCTTCATC365 ENSG00000174130 0.72 ACTCATCTTCTTCTTC-TC 5442A-TCACCTTCTTCTTCATC366 ENSG00000160753 0.72 ATCTAGACCTCCTTCTTCATC 5175ATC—ACCTTCTTCTTCATC367 ENSG00000073331 0.72 A-CAGCCTTCTCCTTCATC 3979ATCA-CCTTCTTCTTCATC368 ENSG00000230040 0.72 ATCACCTTTCCACTTCATC 535 TCACC-TTCTTCTTCATC369 ENSG00000118113 0.72 ATCACCTCTCATCTTCACC 910ATCACCT-TCTTCTTCATC370 ENSG00000159842 0.72 ATCACCTTCCTCTTCCTGC 8875ATCACCTTCTTCTTCAT-C371 ENSG00000164106 0.72 ATTCATCTT-TTCTTCATC 5375A-TCACCTTCTTCTTCATC372 ENSG00000267586 0.72 ATCACCTTCATTTTATTCATC 8512ATCACCTTC—TTCTTCATC373 ENSG00000185532 0.72 A-CACCTTCTT-TATCATC 1671ATCACCTTCTTCT-TCATC374 ENSG00000215580 0.72 ATCACCTTGCTAT-TTCAGTC 690ATCACCTT-CT-TCTTCA-TC375 ENSG00000085999 0.72 ATCACCTTCGTCTTCCACC 2968ATCACCTTCTTCTT-CATC376 ENSG00000105339 0.72 ATCACCTTTCTTC-TCTTC 3554ATCACC-TTCTTCTTCATC377 ENSG00000267665 0.72 ATCACTTTCTTGCTTC-TC 1610ATCACCTTCTT-CTTCATC378 ENSG00000231367 0.72 ATCACCTTGTTTCTT-ATC 1205ATCACCTT-CTTCTTCATCTable 2: Potential target RNAs for svRNA1. ene ID Score Matched Sequence Loci1 ENSG00000196628 0.86 AGATCTTCTTCTTGCCTACTTCTTC 10282A-ATCTTCTTCTTG-CT-CTTCTTC2 ENSG00000183496 0.82 TATCTTCTTCCTGCTCTTCTTC 2447AATCTTCTTCTTGCTCTTCTTC3 ENSG00000102290 0.77 AAT-TTCTTCTTCCTCTTCTCTC 1349AATCTTCTTCTTGCTCTTCT-TC4 ENSG00000174175 0.77 AATCATTCATTCTTG-TCTTCTTGC 2614AATC-TTC-TTCTTGCTCTTCTT-C5 ENSG00000186104 0.77 ATATCTTGCTTCCTGCTCTGTCTTC 4378A-ATCTT-CTTCTTGCTCT-TCTTC6 ENSG00000255767 0.77 AATCTTGCTGTCTTG-TCTTCTTGC 355AATCTT-CT-TCTTGCTCTTCTT-C7 ENSG00000137648 0.73 ACTTCTTCTTCTT-CTTCTTCTTC 9396A-ATCTTCTTCTTGC-TCTTCTTC8 ENSG00000151532 0.73 AATCTT-TTCTT-CTCTT-TTC 3316AATCTTCTTCTTGCTCTTCTTC9 ENSG00000235824 0.73 ATTCTTCTTCATGCTCTTC-TC 43AATCTTCTTCTTGCTCTTCTTC10 ENSG00000145012 0.73 AATCGTTACTATCTTGACTCTTTCCTTC 21971AATC-TT-CT-TCTTG-CTC-TT-CTTC11 ENSG00000169484 0.73 AATCTTCTTCTTGCACTT-TAC 497AATCTTCTTCTTGCTCTTCTTC12 ENSG00000154262 0.73 AAT-TTCTTC-TGC-CTTCTTC 6729AATCTTCTTCTTGCTCTTCTTC13 ENSG00000106588 0.73 AAT-TTCTTCTAGCTCTTC-TC 2481AATCTTCTTCTTGCTCTTCTTC14 ENSG00000184068 0.73 AATCTTCTGCTGCTT-CTGCTTCTTC 76AATCTTCT–T-CTTGCT-CTTCTTC15 ENSG00000185052 0.73 AGAGCTTC-TCTTGCATCTTCTTC 2676A-ATCTTCTTCTTGC-TCTTCTTC16 ENSG00000143669 0.73 AACTCATTCTTCTTTCTCTTCTAC 15026AA-TC-TTCTTCTTGCTCTTCTTC17 ENSG00000189046 0.73 AAT-TTCTTCTT-CTCTTTTTC 1801AATCTTCTTCTTGCTCTTCTTC18 ENSG00000230461 0.73 AATCTTTTTCTTGC-CTT-TTC 2627 ATCTTCTTCTTGCTCTTCTTC19 ENSG00000185745 0.73 AATC-TCTCTCTCTGCTTCCTTCTTC 3813AATCTTCT-TCT-TGC-T-CTTCTTC20 ENSG00000126016 0.73 AAT-TTCTGTCTTGCCTCTCCTTC 6217AATCTTCT-TCTTG-CTCTTCTTC21 ENSG00000144840 0.73 AATCTTCCTTCCTT-CT-TTCTTC 3182AATCTT-CTT-CTTGCTCTTCTTC22 ENSG00000170871 0.73 AAGTCTGTTCTTACTCTAGCTCTTCTTC 1703AA-TC–TTCTT-CT-T-GCTCTTCTTC23 ENSG00000188655 0.73 AATC-TCTCTCTTGCTCCATTTCTTC 1414AATCTTCT-TCTTGCT-C–TTCTTC24 ENSG00000113645 0.73 AATCTTCCTCTTGCTCTCTTTTTC 7531AATCTTCTTCTTG–CTCTTCTTC25 ENSG00000226419 0.73 AATCTT-TATCTTGCTCTACCTTC 6369AATCTTCT-TCTTGCTCT-TCTTC26 ENSG00000168314 0.73 AA-CTCTGTTCTTGCTCTTCATTC 3722AATCT-TCTTCTTGCTCTTC-TTC27 ENSG00000221866 0.73 AATATT-TTCTTGC-CTTCTTC 12807AATCTTCTTCTTGCTCTTCTTC28 ENSG00000033867 0.73 ATCTCTTCTTCTTGGTCATCTTCTTC 1284A-ATCTTCTTCTT-G-C-TCTTCTTC29 ENSG00000152763 0.73 CTTCTTCTTCTTCCTCTTCTTC 1901AATCTTCTTCTTGCTCTTCTTC30 ENSG00000114473 0.73 ATTCATTCTTCTTGCTCTT-TCTC 7232AATC-TTCTTCTTGCTCTTCT-TC31 ENSG00000181852 0.73 AGATCTTACTTTCTTGCTGCTT-TTC 1146A-ATCTT-C-TTCTTGCT-CTTCTTC32 ENSG00000117174 0.73 AATCTTCTATCAGTTGCCCTTTCTTC 2276AATCTTCT-TC–TTGCTC-TTCTTC33 ENSG00000247271 0.73 AATCTACCTTCTGTACTCTTCTTC 1101AATCT-TCTTCT-TGCTCTTCTTC34 ENSG00000070985 0.73 ACGTCTTCTTCTTCCTCTTCTTTC 2630A-ATCTTCTTCTTGCTCTTC-TTC35 ENSG00000133641 0.73 AATATTCTTCTT-CACTTCTTC 5601AATCTTCTTCTTGCTCTTCTTC ene ID Score Matched Sequence Loci1 ENSG00000166908 0.84 ACGCTTCTGCCCCAGTTCCT 759A-GCTTCTGGCCCAGTTCCT2 ENSG00000174243 0.84 AGCTTCTTGGCCCAGTT-CT 4934AGCTTC-TGGCCCAGTTCCT3 ENSG00000280011 0.84 AGCATCTGGCCCCAGTTCCT 7953AGCTTCTGG-CCCAGTTCCT4 ENSG00000145685 0.84 AG-TTCTGGCCCAGTCTCCT 5046AGCTTCTGGCCCAGT-TCCT5 ENSG00000008710 0.79 AGCTTCCTGGCCTCA-TTCCT 14664AGCTT-CTGGCC-CAGTTCCT6 ENSG00000179698 0.79 AGCTTCTGGCCC-GCTCCT 3729AGCTTCTGGCCCAGTTCCT7 ENSG00000198722 0.79 ACGCTTCTGTGCACCAGTTCCCT 1093A-GCTTCTG-GC-CCAGTT-CCT8 ENSG00000131979 0.79 AGCTTCTGGTCCCGGTTTCCT 2034AGCTTCTGG-CCCAG-TTCCT9 ENSG00000254401 0.79 AGCGTTTCTGGCCTCCAGTTCCT 1539AGC–TTCTGG-C-CCAGTTCCT10 ENSG00000071246 0.79 AGCTGTCTGGCCTCAGTTTCCCT 260AGCT-TCTGGCC-CAG-TT-CCT11 ENSG00000142698 0.79 AGCTTCTGTCCCAGTTCCC 1122AGCTTCTGGCCCAGTTCCT12 ENSG00000237945 0.79 AGCTCTCTGGGCCCCAGATTCCT 7297AGCT-TCT-GG-CCCAG-TTCCT13 ENSG00000246582 0.79 AGCCTTTCTGTGACCCAGTTCCT 528AG-C-TTCTG-G-CCCAGTTCCT14 ENSG00000223651 0.79 AGCTTC-GGCCCAATTCCT 1184AGCTTCTGGCCCAGTTCCT15 ENSG00000136002 0.79 AGCTGTCTGGCCC-GATTCCT 1439AGCT-TCTGGCCCAG-TTCCT16 ENSG00000268926 0.79 AGCTTCTCTGAGCCCAGTTTCCT 1670AGC-T-TCTG-GCCCAG-TTCCT17 ENSG00000173846 0.79 AGCTTCTGGCCCAGCCCCT 1765AGCTTCTGGCCCAGTTCCT18 ENSG00000167792 0.79 AGCTTCTGGCCCAATCCCT 871 GCTTCTGGCCCAGTTCCT19 ENSG00000162779 0.79 AGCTTCT-GCCCAGTGCCT 5658AGCTTCTGGCCCAGTTCCT20 ENSG00000173020 0.79 AGCTTGTAGGCCTCAGTTCCT 4483AGCTTCT-GGCC-CAGTTCCT21 ENSG00000178425 0.79 AGCTT-T-GCCCAGTTCCT 188AGCTTCTGGCCCAGTTCCT22 ENSG00000165757 0.79 AGACTTCTGGTGCCCAGATTCCT 4381AG-CTTCT-G-GCCCAG-TTCCT23 ENSG00000077942 0.79 AGCTCTCTGGGCCTCAGTTTCCT 3531AGCT-TCT-GGCC-CAG-TTCCT24 ENSG00000115539 0.79 ACGCTTCTGTG-CCAGTTCCT 177A-GCTTCTG-GCCCAGTTCCT25 ENSG00000139637 0.79 AGCTGCTGGCCCAGTTGCT 673AGCTTCTGGCCCAGTTCCT26 ENSG00000127481 0.79 GGCTTCTGCCCCAGTTCCT 5865AGCTTCTGGCCCAGTTCCT27 ENSG00000142230 0.79 AGCTTCTGGCTCCAGTTGTCT 3132AGCTTCTGGC-CCAGTT-CCT28 ENSG00000118729 0.79 AGCTTGTGGCCCAGGTCCT 473AGCTTCTGGCCCAGTTCCT29 ENSG00000204195 0.74 AGCTTCTGGTCCATGTTTCT 525AGCTTCTGGCCCA-GTTCCT30 ENSG00000171658 0.74 AGCTTCATTGAGCCTCAGCTTCCT 1232AGCTTC–TG-GCC-CAG-TTCCT31 ENSG00000165802 0.74 AGCTTCTGGGCCCA-CTCCT 4313AGCTTCT-GGCCCAGTTCCT32 ENSG00000134184 0.74 AGTCTTCT-GCCCAATTCCT 809AG-CTTCTGGCCCAGTTCCT33 ENSG00000239213 0.74 AG-TATCATGGCTCCAGTTCCT 545AGCT-TC-TGGC-CCAGTTCCT34 ENSG00000176473 0.74 ACCTTCTGAGCCTCAGTTTCCT 4067AGCTTCTG-GCC-CAG-TTCCT35 ENSG00000084693 0.74 AG-TTCTGGCCCAGCCTCCT 4203AGCTTCTGGCCCAG-TTCCT GCTTCT-GGCCCAGTTCCT54 ENSG00000138073 0.74 AGCCTTGTGG-CCAGTTCCT 2946AG-CTTCTGGCCCAGTTCCT55 ENSG00000078808 0.74 AGCTCTCTGTGCCCGAGTTCATCT 3655AGCT-TCTG-GCCC-AGTTC–CT56 ENSG00000197056 0.74 AGCTTACTGGCCCAG-CCCT 4113AGCTT-CTGGCCCAGTTCCT57 ENSG00000168350 0.74 ATG-TTCTGAGCCCAGCTTCCT 4046A-GCTTCTG-GCCCAG-TTCCT58 ENSG00000004777 0.74 AGCTGTCTGGCCCTGCATTCCT 1835AGCT-TCTGGCCCAG–TTCCT59 ENSG00000010803 0.74 CGTCTTCTTGGCCCATGTTCCT 1418AG-CTTC-TGGCCCA-GTTCCT60 ENSG00000158786 0.74 ACGCTTCTTGCCCCAGCTTCCT 3342A-GCTTC-TGGCCCAG-TTCCT61 ENSG00000279072 0.74 AGCCTTTTTTGGCCCAGTTCCT 2629AG-C–TTCTGGCCCAGTTCCT62 ENSG00000179820 0.74 AGCTTCTGGTTCCTATCAGTTCCT 3561AGCTTCTGG–CC—CAGTTCCT63 ENSG00000175215 0.74 AGGCTGTCTGGCACCCAGTGTCCT 4907A-GCT-TCTGG–CCCAGT-TCCT64 ENSG00000229847 0.74 AGTTTCTGGCCCAGTGTCCC 2866AGCTTCTGGCCCAGT-TCCT65 ENSG00000072501 0.74 ACCTTCTGTGCCTCAGTTTCCT 5417AGCTTCTG-GCC-CAG-TTCCT66 ENSG00000276805 0.74 AGCCTTTTTTGGCCCAGTTCCT 3751AG-C–TTCTGGCCCAGTTCCT67 ENSG00000203685 0.74 AGCATTTCTGGCCCACATTCCT 1410AGC–TTCTGGCCCA-GTTCCT68 ENSG00000112541 0.74 TGCTTCCTGAGCCCCAGTTCCT 2744AGCTT-CTG-G-CCCAGTTCCT69 ENSG00000167972 0.74 AGCAATTCTGGGCCATGTTCCT 3999AGC–TTCTGGCCCA-GTTCCT70 ENSG00000133961 0.74 AGGCTTCTGGCCAACAGCTCCT 102A-GCTTCTGGCC–CAGTTCCT GCTTCTGGCCCA-G-TTC-CT89 ENSG00000115592 0.74 AGCCTCTCTGTGCCTCAGTTTCCT 1774AG-CT-TCTG-GCC-CAG-TTCCT90 ENSG00000186469 0.74 AGC-CCTTGGCCCAGTTCCT 2335AGCTTC-TGGCCCAGTTCCT91 ENSG00000103148 0.74 AGCCTTTCCTGGCCCAG-TCCT 5486AG-C-TT-CTGGCCCAGTTCCT92 ENSG00000272556 0.74 AGCCTTTTTTGGCCCAGTTCCT 3440AG-C–TTCTGGCCCAGTTCCT93 ENSG00000253326 0.74 AGCCTTTTTTGGCCCAGTTCCT 4AG-C–TTCTGGCCCAGTTCCT94 ENSG00000165816 0.74 ATGCTTCTGTGCCCCAGATCCT 690A-GCTTCTG-G-CCCAGTTCCT95 ENSG00000183242 0.74 AGTCTCTCTGAGCCTCAGTTTCCT 1576AG-CT-TCTG-GCC-CAG-TTCCT96 ENSG00000178187 0.74 AGCTTTTGACCCAGTTCTCT 484AGCTTCTGGCCCAGTTC-CT97 ENSG00000108219 0.74 AGTCTTTCATGGACCCAGGTTCCT 12861AG-C-TTC-TGG-CCCA-GTTCCT98 ENSG00000263072 0.74 AGCTACTGGGCACCAGTCTCCT 2448AGCTTCT-GGC-CCAGT-TCCT99 ENSG00000237424 0.74 AGCCTTCTGGCCAGCCCAGTTCCT 2295AG-CTTCT-G—GCCCAGTTCCT100 ENSG00000072840 0.74 AGGTTCCTGGCCCAGTTCCC 3482AGCTT-CTGGCCCAGTTCCT101 ENSG00000184261 0.74 AGCTTGCTAGCCCAGCTCCT 1058AGCTT-CTGGCCCAGTTCCT102 ENSG00000143355 0.74 AGCTT-TGGCCACAGTTCCC 1271AGCTTCTGGCC-CAGTTCCT103 ENSG00000198911 0.74 AGGC-TCTGGCCGCAGTGTCCT 1937A-GCTTCTGGCC-CAGT-TCCT104 ENSG00000125637 0.74 AGCTTCTGGCTGCTCAGGTGTCCT 8161AGCTTCTGGC–C-CA-GT-TCCT105 ENSG00000241973 0.74 AGCTTCTGGCACACCAGTTCATCT 7916AGCTTCTGG–C-CCAGTTC–CT
06 ENSG00000092068 0.74 AGCATTGGCTGAAGCCCAGTTCCT 5245AGC-TT–CTG–GCCCAGTTCCT107 ENSG00000251143 0.74 AGCTTCTGGGCCCTGACTTCCT 520AGCTTCT-GGCCC–AGTTCCT108 ENSG00000188612 0.74 AACTTCTGGCCTCAGTCCCT 2825AGCTTCTGGCC-CAGTTCCT109 ENSG00000188039 0.74 AGCCTTCTGTCCCA-TTCCT 6536AG-CTTCTGGCCCAGTTCCT110 ENSG00000225465 0.74 AGCTT-GGGCTCCAGTTCCT 3685AGCTTCTGGC-CCAGTTCCT111 ENSG00000064999 0.74 AGC-TGTGTGCCCAGTTCCT 5195AGCTTCTG-GCCCAGTTCCT112 ENSG00000150995 0.74 ACCTTCTGGCCCTGAGCTTCCT 6417AGCTTCTGGCCC–AG-TTCCT113 ENSG00000226995 0.74 AGTTTCTGGCCTCAGGTCCT 56AGCTTCTGGCC-CAGTTCCT114 ENSG00000279141 0.74 AGCATCTGGGACCCCAGTTCCT 2026AGCTTCT-GG–CCCAGTTCCT115 ENSG00000279440 0.74 AGTCCCTCTGGCCCTAGTTCCT 4346AG–CTTCTGGCCC-AGTTCCT116 ENSG00000233837 0.74 A-CTTCTGCCCCAAGTTCCT 356AGCTTCTGGCCC-AGTTCCT117 ENSG00000230590 0.74 AGACTTCTGGCCTCAAGTAATCCT 17159AG-CTTCTGGCC-C-AGT–TCCT118 ENSG00000060718 0.74 ATGCTTCTGGCATCACAGTTCACT 6479A-GCTTCTGGC–C-CAGTTC-CT119 ENSG00000170322 0.74 AGTTTCTGCCCCAGTTTCCT 1054AGCTTCTGGCCCAG-TTCCT120 ENSG00000182010 0.74 AGCTTCTGGTCCAGTGTCTCAT 1481AGCTTCTGGCCCAGT-TC-C-T121 ENSG00000148187 0.74 AGCTTCTGTGCCCAG–CCT 7955AGCTTCTG-GCCCAGTTCCT122 ENSG00000130830 0.74 AGCCTTCTTGCCCCAGGTTCCT 1667AG-CTTC-TGGCCCA-GTTCCT123 ENSG00000228327 0.74 AGCCTTTTTTGGCCCAGTTCCT 3392 G-C–TTCTGGCCCAGTTCCT124 ENSG00000229433 0.74 AGCCTCTCTGCGCCGCAGTTCCCT 748AG-CT-TCTG-GCC-CAGTT-CCT125 ENSG00000101203 0.74 AGGCTTCTGAGCCCCAAGTTGCCT 601A-GCTTCTG-G-CCC-AGTT-CCT126 ENSG00000149809 0.74 AGCCTGCAGGCCCAGTTCCT 2273AG-CTTCTGGCCCAGTTCCT127 ENSG00000283050 0.74 AGCCTTTTTTGGCCCAGTTCCT 4237AG-C–TTCTGGCCCAGTTCCT128 ENSG00000256028 0.74 AGC-TCTGGCCCCCGAGTTCCT 241AGCTTCTGG–CCC-AGTTCCT129 ENSG00000164073 0.74 ATTCATCTGGCCCAGTTCCT 5201A-GCTTCTGGCCCAGTTCCT130 ENSG00000237438 0.74 AGCCTTCTGCCCCAGTGCCT 2347AG-CTTCTGGCCCAGTTCCT131 ENSG00000119772 0.74 AGTCTTCAGGCCCAGTTTCT 6769AG-CTTCTGGCCCAGTTCCT132 ENSG00000088832 0.74 AG-TTCTGGGGCACCAGTTCCT 498AGCTTCT–GGC-CCAGTTCCT133 ENSG00000180155 0.74 AGCTTTTGGGCCCAG-TCCT 429AGCTTCT-GGCCCAGTTCCT134 ENSG00000149091 0.74 AGCTCCAGGCTCCAGTTCCT 9092AGCTTCTGGC-CCAGTTCCT135 ENSG00000172819 0.74 AGCTAC-GGCCCAGTTCCCT 915AGCTTCTGGCCCAGTT-CCT136 ENSG00000168765 0.74 AGTCTTCT-GCCCAATTCCT 1005AG-CTTCTGGCCCAGTTCCT137 ENSG00000142609 0.74 AGTTTCTGGCCCAG-TCTCT 1363AGCTTCTGGCCCAGTTC-CT138 ENSG00000214837 0.74 AGCCTTTTTTGGCCCAGTTCCT 3757AG-C–TTCTGGCCCAGTTCCT139 ENSG00000168939 0.74 AGC-TCT-GCCCAGTTCTCT 3687AGCTTCTGGCCCAGTTC-CT140 ENSG00000178188 0.74 AGCTGCTCTGGCCCCAG-TCCT 2194AGCT–TCTGG-CCCAGTTCCT
41 ENSG00000164855 0.74 AGCCTCTCCTGGCCTCAGTATCCT 5633AG-CT-T-CTGGCC-CAGT-TCCT142 ENSG00000260404 0.74 AGCCTTTTTTGGCCCAGTTCCT 2012AG-C–TTCTGGCCCAGTTCCT143 ENSG00000228696 0.74 AGCTT-TGGCCCAGTGCCCT 3341AGCTTCTGGCCCAGT-TCCT144 ENSG00000205176 0.74 AGACTGCTGGCCCAG-TCCT 6432AG-CTTCTGGCCCAGTTCCT145 ENSG00000111325 0.74 AGC-TCTGGCCCCCGAGTTCCT 1749AGCTTCTGG–CCC-AGTTCCT146 ENSG00000174405 0.74 AGTCTTCTGGCGCCAGCTTCCG 206AG-CTTCTGGC-CCAG-TTCCT147 ENSG00000177084 0.74 CGCTCTCTGGCCCAGTTCAGCT 9130AGCT-TCTGGCCCAGTTC–CT148 ENSG00000171700 0.74 AGCTGGCTGGCCCAGTGCTCCT 1605AGCT-TCTGGCCCAGT–TCCTTable 4: Potential target RNAs for svRNA3 (truncated version). ene ID Score Matched Sequence Loci1 NC000002.12 chr2 0.89 GAGGAAGAAGAAGGTGAT 134222364GATGAAGAAGAAGGTGAT2 NC000003.12 chr3 0.89 GATAAAGAAGAAGGTGAT 62430918GATGAAGAAGAAGGTGAT3 NC000012.12 chr12 0.89 GATGCAAGATAGAAGGTGAT 43685381GATG-AAGA-AGAAGGTGAT4 NC000012.12 chr12 0.89 GAT-AAGAAGAAGGTGAT 22739819GATGAAGAAGAAGGTGAT5 NC000007.14 chr7 0.89 GATGAATGAAGAAGGTGCAT 690091GATGAA-GAAGAAGGTG-AT6 NC000007.14 chr7 0.89 GATGAAGAAGAAGGT-AT 5993096GATGAAGAAGAAGGTGAT7 NC000011.10 chr11 0.89 GATG-AGAAGAAGGTGAT 33698282GATGAAGAAGAAGGTGAT8 NC000015.10 chr15 0.89 GAAGAAGAAGAAGGTGAT 13363820GATGAAGAAGAAGGTGAT9 NC000015.10 chr15 0.89 GAAGAAGAAGAAGGTGAT 5648009GATGAAGAAGAAGGTGAT10 NC000006.12 chr6 0.89 GAAGAAGAAGAAGGTGAT 39349582GATGAAGAAGAAGGTGAT11 NC000003.12 chr3 0.89 GATGATAGAAGACAGGTGAT 38020582GATGA-AGAAGA-AGGTGAT12 NC000003.12 chr3 0.89 GATGAAGAAAAAGGTGAT 52630276GATGAAGAAGAAGGTGAT13 NC000004.12 chr4 0.89 GATGAAGAAGAAGG-GAT 88689121GATGAAGAAGAAGGTGAT14 NC000003.12 chr3 0.89 GATGAAG-AGAAGGTGAT 96774073GATGAAGAAGAAGGTGAT15 NC000006.12 chr6 0.89 GATCAAGAAGAAGGTGAT 68689908GATGAAGAAGAAGGTGAT16 NW021160000.1 chr10patch FIX 0.83 GATGTAGAAGACAGGTGAT 376177GATGAAGAAGA-AGGTGAT17 NC000009.12 chr9 0.83 GATGCAGAAGACAGGTGAT 5316996GATGAAGAAGA-AGGTGAT ATGAAGAAGA-AGGTGAT53 NC000002.12 chr2 0.83 GATGAAAGAAAGAGAGGTGAT 50153821GATG-AAG-AAGA-AGGTGAT54 NC000002.12 chr2 0.83 GATGAAGAAG-AGGTGAGT 54757052GATGAAGAAGAAGGTGA-T55 NC000001.11 chr1 0.83 GATGAAGAAGGACAGGTGAGT 8230241GATGAAGAA-GA-AGGTGA-T56 NC000001.11 chr1 0.83 GAGTGAAGGAAGAAAGGTGAT 11457065GA-TGAA-GAAG-AAGGTGAT57 NC000001.11 chr1 0.83 GAATGAAGGAAGGAAGGTGAT 20218652G-ATGAA-GAA-GAAGGTGAT58 NC000014.9 chr14 0.83 GATAGAAGATAGAAGGTGAGT 3500879GAT-GAAGA-AGAAGGTGA-T59 NC000014.9 chr14 0.83 GATGAAGAAGGAGGGTGAT 5524784GATGAAGAA-GAAGGTGAT60 NC000014.9 chr14 0.83 GATGCAGAAGACAGGTGAT 33473013GATGAAGAAGA-AGGTGAT61 NC000011.10 chr11 0.83 GATGAAGAATAAGGTGTAT 30461125GATGAAGAAGAAGGTG-AT62 NC000014.9 chr14 0.83 GATGATAGATAGATAGGTGAT 37879808GATGA-AGA-AGA-AGGTGAT63 NC000014.9 chr14 0.83 GATGTAGAAGACAGGTGAT 40769989GATGAAGAAGA-AGGTGAT64 NC000014.9 chr14 0.83 GAATGAAGAAGTAGGTGAT 51367085G-ATGAAGAAGAAGGTGAT65 NC000014.9 chr14 0.83 GATGAAGTAGGAAGGTGAT 51525290GATGAAG-AAGAAGGTGAT66 NC000014.9 chr14 0.83 GATGAAGAAGATAGGGGAT 53156856GATGAAGAAGA-AGGTGAT67 NC000014.9 chr14 0.83 GA-GAAGAAGAAGGTGAAT 74516204GATGAAGAAGAAGGTG-AT68 NC000012.12 chr12 0.83 GATGCAGAAGACAGGTGAT 1020657GATGAAGAAGA-AGGTGAT69 NC000012.12 chr12 0.83 GATGCAGAAGACAGGTGAT 1527615GATGAAGAAGA-AGGTGAT -ATGAAGAAGAAGGTGAT87 NC000004.12 chr4 0.83 GAGGAAGAAGAAGAGTGAT 76308292GATGAAGAAGAAG-GTGAT88 NC000004.12 chr4 0.83 GATGAAGAACGAAGGTAAT 73534765GATGAAGAA-GAAGGTGAT89 NC000004.12 chr4 0.83 GAATGCAGAAGAAGGTGAT 62458987G-ATGAAGAAGAAGGTGAT90 NC000020.11 chr20 0.83 GATGAAGCAA-AAGGTGAT 18580374GATGAAG-AAGAAGGTGAT91 NC000016.10 chr16 0.83 GATGAAGAAGAAGATTGTGAT 37225026GATGAAGAAGAAG—GTGAT92 NC000016.10 chr16 0.83 GATGAAGAAGGAAGGTATGAT 34440755GATGAAGAA-GAAGG–TGAT93 NC000016.10 chr16 0.83 GATGAAGAAGGAAGGT-AT 34440752GATGAAGAA-GAAGGTGAT94 NC000016.10 chr16 0.83 GATGCAGAAGACAGGTGAT 17439087GATGAAGAAGA-AGGTGAT95 NC000016.10 chr16 0.83 GATGAAGAAG-AGGTAGAT 16213349GATGAAGAAGAAGGT-GAT96 NC000016.10 chr16 0.83 GATGCAGAAGACAGGTGAT 4949206GATGAAGAAGA-AGGTGAT97 NC000019.10 chr19 0.83 GATGAAGAAGAAGTGTG-T 18521261GATGAAGAAGAAG-GTGAT98 NC000019.10 chr19 0.83 GCATGAAGAGAGAAGGTGACT 19625401G-ATGAAGA-AGAAGGTGA-T99 NC000018.10 chr18 0.83 GATGAAGAAGCAGCAGGTGAT 2511062GATGAAGAAG-A–AGGTGAT100 NC000018.10 chr18 0.83 GATGAAGAAGATACGTGAT 3244108GATGAAGAAGA-AGGTGAT101 NC000018.10 chr18 0.83 GATGCAGAAGACAGGTGAT 12177624GATGAAGAAGA-AGGTGAT102 NC000018.10 chr18 0.83 GATGAAGAAGAAGGATCGTAT 14560185GATGAAGAAGAAGG-T-G-AT103 NC000003.12 chr3 0.83 GATGAAGAAGGAAGGTGA- 10434487GATGAAGAA-GAAGGTGAT