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D-dimer and COVID-19: Why can it predict the disease?
During the COVID-19 pandemic, the scientific community discovered a significant correlation between D-dimer, an important biomarker, and COVID-19 symptoms. D-dimer is a fibrin degradation product. This small protein fragment will only appear in the blood after the blood clot has been dissolved by fibrinolysis. Its concentration changes can be used to assist in the diagnosis of thrombotic symptoms such as venous thromboembolism, and become an important indicator for assessing the condition of COVID-19 patients.
Changes in D-dimer concentrations can help medical staff predict the condition and possible complications in COVID-19 patients.
D-dimer testing is used to rule out the possibility of blood clots, and in COVID-19 patients, elevated D-dimer levels indicate potential serious complications, with levels rising more than fourfold and being an indicator of poor prognosis for hospitalized patients. one. This means that in the face of the challenges of COVID-19, D-dimer is not only a tool to exclude thrombosis, but also an important reference for predicting the development of lesions.
Biological principles of D-dimer
The formation process of D-dimer involves multiple biological pathways such as blood coagulation and fibrinolysis. When the body's coagulation system is activated, coagulation proteins become activated, eventually leading to the formation of a blood clot. D-dimer is released into the blood only after the fibrinolysis process. The complexity of this process allows changes in D-dimer to reflect the state of blood coagulation in the body.
Clinical Application of D-dimer
The detection of D-dimer is mainly used in clinical practice when deep vein thrombosis, pulmonary embolism or diffuse intravascular coagulation is suspected. Doctors can use the D-dimer test to help assess the condition. When the D-dimer test result is negative, the possibility of thrombosis can be almost ruled out. This property makes it particularly important in the management of COVID-19 patients, who are more susceptible to complications such as blood clots.
In the management of COVID-19, the test results of D-dimer can provide important reference for medical decision-making.
Interpretation of D-dimer
The normal range of D-dimer increases with age, so for patients over 50 years of age, a suggested reference value is the patient's age multiplied by 10 μg/L. In addition, false-positive and false-negative results of D-dimer can be affected by a variety of factors, including liver disease, inflammation, pregnancy, and surgery. This requires caution in interpreting test results and taking into account the patient's clinical condition.
D-dimer exploration during the COVID-19 pandemic
Studies have shown that increased levels of D-dimer may be associated with severe cases of COVID-19. This makes the D-dimer test a simple and effective tool for evaluating a patient's condition. As our understanding of COVID-19 deepens, the application of D-dimer may be further expanded in the future to cover a wider range of clinical studies.
In the treatment of COVID-19 patients, D-dimer provides important information about the progression of the disease, allowing medical staff to better formulate treatment plans.
As research into D-dimer’s role in COVID-19 continues, the scientific community may discover more applications. We can't help but ask, will D-dimer become a standard tool or even a key indicator in future epidemic management?
