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Kidney health warning signs: Why fever and rash may indicate kidney problems
Kidney health is an important indicator of overall health, and paying attention to kidney warning signs can help people detect potential diseases early. Recent medical research has found that common symptoms such as fever and rash may be closely related to kidney problems, which has given the medical community new insights into the identification of kidney disease.
Renal interstitial nephritis, also known as tubulointerstitial nephritis, is a disease in which the kidney's interstitium becomes inflamed, the area containing cells, extracellular matrix, and fluid surrounding the kidney tubules.
This condition is mostly due to inflammation caused by certain medications, environmental factors, infections or systemic diseases. Studies have shown that the clinical presentation of this disease can range from an acute process to a chronic condition that may eventually lead to renal insufficiency.
Common symptoms
The symptoms of interstitial nephritis of the kidney range widely, one of the most common is fever, which occurs in 30-50% of patients. This phenomenon is particularly prominent in drug-induced interstitial nephritis. In addition, patients may experience nonspecific symptoms such as nausea, vomiting, fatigue, loss of appetite, and weight loss.
Although the "classic triad of symptoms" mentioned in early literature is rash, joint pain, and increased eosinophils in the blood, recent epidemiological studies have shown that such symptoms only occur in a small number (5-10%) of patients. Appeared in.
In addition to these general symptoms, people with kidney problems may also experience more specific symptoms such as side pain, pain when urinating, and significant blood in the urine. High blood pressure is also an important indicator.
Potential Causes
Common causes of interstitial nephritis in the kidneys include infection or a reaction to certain medications such as pain relievers, anti-inflammatory drugs, or antibiotics (such as mecillinam). The study found that 71% to 92% of cases were caused by a reaction to the medication.
There is evidence that beta-lactam antibiotics, such as penicillin and cephalexin, and nonsteroidal anti-inflammatory drugs, such as aspirin, may also trigger this condition.
In acute tubulointerstitial nephritis, patients may experience an increase in eosinophils as part of the diagnosis, while chronic disease may result in malnutrition, hypokalemia, and metabolic acidosis. Various problems.
Diagnostic Methods
IDN can be diagnosed by noninvasive methods, such as physical examination, blood and urine tests, or imaging studies. However, a definitive diagnosis still requires tissue diagnosis through a kidney biopsy.
Pathological examination reveals interstitial edema and leukocytic infiltration, usually sparing blood vessels and glomeruli.
It should be noted that if acute tubulointerstitial nephritis is caused by an allergic reaction, typical symptoms include fever, rash, and enlarged kidneys, while the manifestations of chronic nephritis are associated with nausea, vomiting, and loss of appetite.
Treatment and Prognosis
The key to treating interstitial nephritis is to eliminate the drugs that cause the disease. Although corticosteroids are being used increasingly, there is currently no clear evidence that they help all patients. As kidney function declines, some people may even need dialysis or a kidney transplant.
In most cases of acute tubulointerstitial nephritis, kidney function will recover after the offending drug is stopped or the underlying disease is treated, but chronic tubulointerstitial nephritis cannot be cured.
If there is a family history of kidney disease, or if you have ever experienced symptoms such as fever or rash, you should actively seek medical advice. Early identification of kidney disease is key to long-term health maintenance; failure to do so may result in serious health consequences. How can you detect these potential warning signs early and protect your kidney health?
