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Magical scaffolds: How do these materials dissolve perfectly in the body?
With the rapid development of medicine, bioresorbable stents have gradually become a new trend in cardiovascular interventional treatment. This new type of stent can not only expand blocked heart arteries, but also be slowly absorbed by the body after the treatment process is completed, and eventually disappear from the human body. The use of bioresorbable stents offers greater hope and possible benefits to patients than traditional metal stents, especially when many long-term complications are effectively avoided.
Bioresorbable stents are devices designed to open and widen blocked heart arteries and then dissolve, or be absorbed, in the body.
Although traditional metal stents are effective in treatment, they may cause a series of subsequent problems, such as increased risk of thrombosis, prevention of vascular adaptive or expansile remodeling, and even affect subsequent surgical intervention. Bioresorbable stents are designed to overcome these problems, providing an effective solution that supports blood vessels while eventually disappearing on its own.
Choice of base materials
The basic materials of bioresorbable stents are mainly divided into two categories: metals and polymers. Although polymer stents initially had a strong market share, as safety issues arose, more and more researchers began to turn to the development of metal-based stents, especially magnesium-based stents.
Metal-based bracket
There are several candidate materials for metal stents on the market, including magnesium, iron, zinc and their alloys. Magnesium-based stents have been approved for use in many countries around the world and are characterized by being approximately 95% absorbed within one year of implantation. Results from many clinical trials have shown that magnesium-based stents can effectively avoid the defects of permanent metal stents in terms of functionality. Through special alloys, coatings and other technologies, researchers are working to slow down the corrosion of magnesium and improve its safety.
Clinical results show that magnesium-based stents are a viable option that effectively avoids the disadvantages of permanent stents.
Polymer-based scaffolds
Polymer-based scaffolds, such as poly (L-lactic acid) (PLLA), have been approved in some countries. These materials can be gradually broken down into lactic acid in the body without leaving any harmful substances. However, the performance of polymer stents has raised significant safety concerns, and market demand has decreased. The "Absorb" stent is an example, but it was eventually eliminated from the market due to poor performance.
Clinical research results
Multiple clinical studies have shown that the effectiveness and safety of bioresorbable stents are comparable to those of drug-eluting stents. Specifically, Magmaris' magnesium-based stents have been reported to have low rates of target lesion failure and stent thrombosis, demonstrating superiority over conventional stents. These studies undoubtedly provide new references for future treatments.
History
In the United States, the first fully absorbable stent was approved by the FDA in 2016. Its development marks a major leap forward in cardiovascular interventional technology and opens a new chapter in cardiovascular treatment.
Bioresorbable scaffolds can support blood vessels and eventually be absorbed by the body when no longer needed, achieving natural blood vessel reconstruction.
The emergence of this stent is not only a breakthrough in cardiovascular intervention technology, but also a reflection of future medical progress. As we continue to explore biomaterial technology, this field will usher in more innovations and challenges. In the future, will we be able to witness more similar "magical" medical technologies to improve human health and life?
