In the chemistry community, there is often heated discussion about who is the greatest chemist. In the field of chemistry in the 20th century, Robert Robinson and Robert Burns Woodward are undoubtedly two giants that cannot be ignored. Both have made landmark contributions to the achievements of chemical synthesis and have had a profound impact on the total synthesis of biomolecules in their respective research fields. Among them, the most eye-catching is their research on the total synthesis of strychnine.
The competition between Robinson and Mudehua is not only a contest of chemical technology, but also a comprehensive reflection of innovation ability and scientific research spirit.
Maruk is a toxic alkaloid from Strychnos ignatii, its scientific name is C21H22N2 > O2, there are complex structures with up to seven rings. In the 1950s, Mudehua pioneered the Marek synthesis method, an achievement considered a milestone in chemistry.
Robinson not only made great contributions to the determination of chemical structures, but also laid the foundation for chemical identification in his work in 1947. His literature includes more than 250 journal articles, and his winning of the 1947 Nobel Prize in Chemistry reflects not only his diligence but also his in-depth research on alkaline compounds.
Robinson said: "Marik is the most complex substance known so far. The precision of the structure of this molecule is awe-inspiring."
Although Mu Dehua's publication in 1954 was only three pages long, he described the synthesis process very concisely. In a subsequent lengthy paper in 1963, he further detailed the various steps, including the use of different chemical reactions, to build the complex structure of Marik.
In this competition for the synthesis of Marik, in addition to Robinson and Mudwar, many other chemists participated, such as Magnus, Overman, Rawal, and others. ) and so on, each of which contributed different synthesis methods. This competition also symbolizes cooperation and communication within the academic community. Many scientists have improved on each other's discoveries, thereby advancing the progress of this research field.
Although different synthesis methods have different paths, they all point to the same goal - the total synthesis of Marik, showing the infinite possibilities of scientific exploration.
With the advancement of science and technology, many problems that are still being studied today have become challenges for some outstanding scientists in that era. This competition on Marik synthesis not only allows us to see the wisdom of the chemical community, but also gives us insight into the diversity and challenges of chemical research. Today, our researchers can build on the work of their predecessors and explore the mysteries of the chemical world in greater depth.
Robinson and Mudehua's efforts in Marik synthesis have continuously spawned new synthetic methods and inspirations. As for the future of chemistry, how should today's chemists inherit and develop their spirit and technology?< /p>