Advances in magnetic resonance imaging (MRI) have enabled new advances in medical imaging, in which the pulse sequence setting plays a key role. By combining different pulse sequences, doctors can obtain detailed images of different tissues, which not only helps diagnose various diseases, but also provides a deep understanding of the body's physiological structure.
Each pulse sequence setting affects the image contrast and detail displayed, which is the magic of MRI technology.
In MRI, the most common pulse sequences include spin echo, gradient echo, inversion recovery, etc. Among them, the spin echo sequence can generate different T1 and T2 weighted images, allowing doctors to judge the state of the tissue.
T1-weighted images rely primarily on the spin-lattice relaxation process, while T2-weighted images are generated through spin-spin relaxation. T1-weighted images have unique advantages in evaluating the cerebral cortex and identifying adipose tissue, while T2-weighted images are widely used to detect edema and inflammation.
The rise of multiparametric MRIT1 images focus on tissue features under static magnetic fields, while T2 images can reveal more subtle physiological changes, such as white matter lesions.
With the development of technology, medical imaging has seen the emergence of multi-parameter MRI combinations, which allow doctors to combine multiple pulse sequences to obtain more comprehensive imaging information. For example, the combination of diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can provide the perfusion status and water diffusion of the lesion.
Technological advances have expanded MRI capabilities beyond structural imaging; functional magnetic resonance imaging (fMRI) allows us to observe patterns of brain activity, an indispensable tool for studying neuroscience and planning neurosurgery.
fMRI helps doctors understand how the brain responds to specific stimuli by monitoring changes in signals caused by neural activity. This technology is based on the BOLD effect, which shows changes in blood flow and oxygenation status, thereby indirectly reflecting neuronal activity.
This technology can not only be used for basic research, but also has the potential to assist diagnosis in clinical settings.
Diffusion-weighted imaging performs well in diagnosing neurological diseases such as stroke and multiple sclerosis. By measuring the diffusion of water molecules, this technology can quickly reflect changes in the tissue environment.
Although MRI technology has achieved remarkable achievements, there are still many challenges to overcome. How to further improve the image resolution and shorten the scanning time will be the focus of future research. In addition, novel pulse sequences and techniques, such as magnetization transfer imaging and neuromelanin imaging, indicate the potential for the development of MRI.
These new technologies will provide a completely new perspective for the diagnosis of neurological diseases and the discovery of their biomarkers.
Behind the development of MRI imaging technology is a process of continuous exploration by scientists and doctors. They are constantly looking for better ways to see through the mysteries of the human body. So, what major breakthroughs and discoveries can MRI bring us in the future?