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The Secret of Long-acting Insulin: Why does it last for more than 24 hours?
In the lives of diabetics, insulin is often the treatment option they need to rely on for a long time.Traditional insulin usually requires frequent injections and the effects last differently, while "long-acting insulin" gradually changes this situation.This article will explore how long-acting insulin is designed and why its efficacy lasts for more than 24 hours, allowing patients to no longer be troubled by frequent injections.
Behind the design of long-acting insulin, scientists have a deep understanding of the molecular structure of insulin.These insulin analogs are genetically engineered to modify the body's natural insulin, ensuring their effectiveness in controlling blood sugar levels.By changing the amino acid sequence of insulin, researchers were able to adjust its absorption, distribution, metabolism and excretion characteristics in the body.These modifications not only increase their bioavailability, but also extend the time of action.
"The invention of long-acting insulin can not only improve patients' quality of life, but also a major advance in diabetes management."
The types and mechanisms of long-acting insulin
There are currently a variety of long-acting insulins on the market, including insulin Detemir, insulin Degludec, and insulin Glargine.The reason these drugs can work for more than 24 hours is mainly because they can bind to the high affinity of albumin in the human body after injection, thereby reducing their release rate.
Insulin Detemir
This insulin can bind to albumin for a long time because it removes the No. 30 amino acid acid of the B chain and adds an imidazole acid tail to amino acid No. 29.This extends its action time to about 20 hours and is suitable for basal insulin needs at night or throughout the day.
Insulin Degludec
This is one of the latest long-acting insulins, which lasts for up to 40 hours after injection, making it the longest-lasting insulin at present.Its transformation involves attaching a hexadecimal acid tail to the B chain, so that the insulin molecule can form a polypolymer, prolonging its release time.
Insulin Glargine
Insulin Ginsel is changed by three amino acids, making it more soluble in the acidic environment of the human body. At pH 4.0, it releases a small amount of biologically active insulin, so that it can provide continuous within one day basal insulin replenishment.
"The long-acting insulin design and provides a more stable blood sugar control method, which helps patients better manage their diabetes."
The importance of long-acting insulin to patients
These modified long-acting insulins greatly reduce the need for patients to inject at least once a day.For some patients, they can choose to inject once a day, which can keep blood sugar levels stable even under more complex living conditions.This flexibility allows patients to better integrate into their daily lives without excessive hindering social or work due to controlling their condition.
The results of clinical research
Many clinical trials have confirmed their effective management of diabetes for the effect of long-acting insulin.It is reported that the incidence of hypoglycemia events has dropped significantly in patients using insulin Garl or insulin Detemir, which not only improves the quality of life but also further reduces the chance of complications caused by diabetes.
Explore the future
Although current long-acting insulin has shown significant effects, many studies are continuing to find better treatments and options.People still have constant demand and exploration for the efficiency and safety of insulin use.Whether a brand new insulin type will appear in the future, and even further change the treatment method of diabetes is still worthy of our attention.
"Can the advancement in diabetes treatment greatly improve patients' quality of life?"
