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The secret of MAGIC glue: Why can it overcome the limitation of oxygen?
In the field of radiotherapy, accurate measurement of absorbed radiation dose is crucial to the effectiveness of treatment. For decades, scientists have explored the use of gel dosimeters to achieve this goal, particularly in studying the effects of radiation on different materials. This article will discuss in depth the creation of MAGIC colloid and how it overcomes the oxygen limitation issues faced by previous colloid dosimeters and demonstrate its potential for clinical applications.
The development history of colloid dosimeter
Colloidal dosimeters, also known as Fricke colloidal dosimeters, are composed of radiation-sensitive chemicals that, after exposure to radiation, undergo radical changes based on the absorbed radiation dose. As early as 1950, scientists used radiation-induced color changes of dyes to investigate the issue of radiation dosage in colloids. In 1984, Gore et al. used nuclear magnetic resonance (NMR) technology for the first time to measure the changes in Fricke dosimeter solutions, laying the foundation for the subsequent development of colloid dosimeters.
Fricke dosimeters have always faced challenges due to their unstable spatial dose distribution.
Innovation of MAGIC glue
After entering the 21st century, the introduction of MAGIC glue marked a major breakthrough in colloid dosimeter technology. The MAGIC glue formula combines methacrylic acid, ascorbic acid, gelatin and copper to cleverly capture oxygen from the air, thereby eliminating the problem of oxygen inhibiting polymerization. This technology allows MAGIC glue to be manufactured in the laboratory without the need for a specially controlled oxygen environment.
Principles of oxygen interception
In MAGIC gel, ascorbic acid acts as an oxygen scavenger that can effectively combine free oxygen with the colloidal mixture to form metal-organic complexes, a process triggered by copper sulfate. This approach not only avoids the effects of oxygen inhibition, but also enables existing colloid dosimeters to be more widely used in clinical applications.
Combination of MAGIC glue and clinical application
As MAGIC glue technology matures, various studies and clinical trials have been launched. Many studies have shown that the accuracy and stability of MAGIC glue in radiotherapy are better than traditional colloid dosimeters. It can not only be used in a variety of radiotherapy treatments, but also effectively identify the heterogeneity of human tissues and improve therapeutic effects.
The development of MAGIC glue provides a new solution for radiation dose measurement, attracting the attention of many scientific researchers.
Future Challenges and Prospects
Although MAGIC glue has made considerable progress in technology, it still faces some challenges. For example, research on material stability and biocompatibility is still ongoing. Future research may focus more on improving the molecular structure stability of MAGIC glue and broadening its clinical application areas.
Conclusion
With the continuous advancement of science and technology, the scientific theory behind MAGIC glue is becoming clearer and its clinical application scope is becoming wider. Will the success of this technology continue to play a role in solving medical problems?
