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Why is high NM23 expression a key indicator of cancer survival?
Cancer treatment is not only focused on destroying the primary tumor, but more importantly, preventing its metastasis. Tumor metastasis is the main cause of death in cancer patients, and studies have shown that the metastasis process is the key to the mortality of many cancers. In this context, high expression of the NM23 gene has attracted attention because it may become an important indicator of cancer survival.
Tumor metastasis is the leading cause of cancer death in humans, and metastasis inhibitors such as NM23 may help improve survival rates.
The role of NM23
NM23 is a metastasis suppressor, and its high expression is associated with good prognosis, especially in various tumor types such as breast and ovarian cancer. Studies indicate that cancer patients with high NM23 expression generally have better survival rates and higher efficacy responses after treatment.
Ovarian cancer patients with high expression of NM23 have a better response to drug treatment and have an increased chance of survival.
Healing recipes
Many deadly cancers, such as pancreatic and lung cancer, attribute much of their improvement in survival rates to advanced surgery, radiation and chemotherapy techniques. Despite this, these treatments often do not significantly improve patient survival, especially when faced with metastatic cancer. The expression of NM23 can be used as a therapeutic indicator to help medical personnel choose appropriate treatment strategies, especially in the case of metastatic tumors.
Biological mechanism
NM23-H1 and NM23-H2 in the NM23 gene family have been found to have metastatic inhibitory effects on various types of tumors. These proteins inhibit the metastatic behavior of cancer cells through various pathways, such as affecting cell signaling and regulating the organization of the cytoskeleton.
NM23 effectively inhibits the metastasis of tumor cells by changing intracellular signaling pathways.
Clinical Application
Clinically, high expression of NM23 can not only help predict the survival status of patients, but also serve as a guide for treatment. When treating cancer, if the expression of NM23 can be increased, it may help improve the prognosis of patients. A positive correlation between NM23 expression and treatment response also emerged in patients with ovarian and esophageal cancer.
Looking to the future
As our understanding of metastasis suppressors and their mechanisms of action increases, NM23 may become integral to future cancer therapies. The discovery of these proteins not only provides new biomarkers to predict prognosis, but may also lead to new treatment strategies to block the tumor metastasis process and win more survival opportunities for patients.
NM23 and other metastasis suppressors provide key biomarkers to help adjust treatment strategies and improve prognosis.
With the progress of research, can we use NM23 to develop more effective cancer treatments in the future, making it a hope for survival for patients with metastatic cancer?
