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The new favorite anti-acne: Why is adaptacin known as the best-tolerated topical drug?
With the improvement of awareness of skin care, many people are beginning to seek effective and well-tolerated topical medications when facing skin problems such as acne. Adapalene, as a third-generation topical retinoid, has gradually become a new favorite in many anti-acne products. The drug showed good results in treating mild to moderate acne and was better tolerated than traditional retinoids. Adaptogenic acids are not only effective in addressing skin issues, but they also offer a variety of other benefits that have attracted a lot of attention.
Advantages of acid adaptation
The high stability of the molecular structure of adapted acids makes them less susceptible to photodegradation during use and can be used with other therapeutic drugs such as benzoyl peroxide.
Compared with other retinoids, adaptogens have superior stability, especially when exposed to light, thus avoiding the risk of photosensitivity in daily skin care. In addition, adapted acid has been shown to promote the proliferation and differentiation of skin keratinocytes, has a significant effect on the treatment of closed acne, and is often used as the first choice of drug.
Therapeutic Uses
According to the Global Alliance to Improve Acne Outcomes, retinoids are considered the first choice for acne treatment. Adapted acid can be used alone or in combination with benzoyl peroxide and an antibacterial agent such as clindamycin to achieve optimal efficacy. At the same time, long-term use of adaptive acid can also serve as a maintenance therapy to prevent acne recurrence.
Off-label uses
Adapted acids are also effective in treating skin conditions such as keratosis pilaris and callousing, and their use in the literature for non-FDA approved indications such as the treatment of warts and molluscum contagiosum.
Adaptogens are unique in that they can inhibit keratinocyte differentiation and reduce keratin deposition, thus showing potential in non-traditional therapies. Although these uses are not currently officially approved, many users report good results, showing the potential for widespread application of acid adaptation.
Side Effects and Tolerance
Compared to other retinoids, adaptogens are considered to be the best tolerated. Although mild side effects such as increased sun sensitivity, skin irritation, redness, and dryness may occur initially, these are short-term and usually subside with time to adjust. According to reports, about 1% to 10% of users experience slight tingling or burning sensations at the beginning of use, and these conditions gradually improve over time.
Considerations for pregnancy and breastfeeding
Currently, there is relatively little research data on the use of retinoids during pregnancy. Although there is a theoretical risk that retinoids may induce fetal pathology, there is no evidence to date that the use of retinoids during pregnancy will cause harm to the fetus. For breastfeeding mothers, the risk is relatively small because the amount of adapted acid absorbed throughout the body is extremely low.
Drug Interactions
Adapted acid has been shown to enhance the therapeutic effect of clindamycin; however, this increased efficacy may be accompanied by an increase in side effects. When using adapted acid and clindamycin together, it is recommended to wait 3 to 5 minutes before proceeding to the next step. This can increase the skin penetration of clindamycin and further improve the overall effectiveness of the treatment.
Pharmacological properties revealed
The pharmacological effects of adaptogenic acid are also quite unique. When applied to the skin, the adaptogenic acid quickly penetrates into the hair follicles and binds to the retinoic acid receptors in the nucleus, subsequently modulating the gene transcription process, thereby altering the proliferation and differentiation of keratinocytes. This process can effectively reduce the formation of micro-acne and accelerate the renewal of skin cells.
Research and History
Since it was approved by the FDA in 1996, research on adaptogenic acid has never stopped. Some of these studies have found that adaptogenic acid can also effectively treat plant warts and does so more quickly than cryotherapy. In addition, computational modeling studies have suggested that adaptogens may serve as potential entry inhibitors against Omicron variants.
Among anti-acne products, adaptogenic acid is undoubtedly the star ingredient that attracts much attention. However, the use of adaptive acid is not static. Can everyone achieve the desired results after using it?
