The secret of low-frequency ultrasound: Why does it make neurons active?

In today's rapidly developing medical technology, the potential of low-frequency ultrasound is attracting more and more attention. Since 2002, this technology has been intensively studied, especially in the field of neurology. Low-frequency pulsed ultrasound (TPU) is a method that uses low-intensity, low-frequency ultrasound to stimulate the brain. Its innovative and non-invasive nature opens up new possibilities for neuromodulation.

“Low-frequency ultrasound is not only a treatment technology, but also a window to new knowledge in neuroscience.”

Research and Application

Since 2010, research on TPU has mainly focused on treating neurological disorders and improving cognitive function. The technology's applications continue to expand as research into the possibility of stopping epileptic seizures unfolds. Clinical trials are currently underway in a variety of mammals with the hope of having a positive impact on the treatment of conditions such as epilepsy, Parkinson's disease, chronic pain, coma, dystonia, psychosis and depression.

Developments in the medical field

Scientists look forward to incorporating TPU into standard medical practice, as the technology's potential encompasses a variety of benefits. They used safe, low-strength TPU to test various animals, and preliminary results showed that it could help improve symptoms and quality of life.

Potential for military applications

The U.S. Defense Advanced Research Projects Agency (DARPA) is studying how to use TPU to develop a helmet that can control soldiers' mental stress. The technology is expected to be effective in regulating stress and anxiety among soldiers. In practice, the sound waves would be precisely targeted at specific areas of the brain and modulated without damaging surrounding tissue.

“This may become a revolutionary development in improving the psychological stability of soldiers when performing tasks.”

Test methods and results

The mechanism of action of low-frequency TPU is still being explored. Early research shows that it can improve the behavioral control ability of animals and change the electrical properties of cells, that is, the functionality of neurons. Therefore, when focused on the motor cortex of an animal's brain, TPU can cause its limbs to move without changing the structure or function of this area.

Limitations

Although TPU showed no lasting neurological abnormalities in preliminary trials, the technology is still relatively new and long-term side effects are unknown. Although it is a non-invasive alternative treatment, the potential risks require further study.

Therapeutic Benefits

Low-frequency ultrasound has many advantages over high-frequency ultrasound, such as lower tissue absorption rate, greater physical penetration depth, and higher patient safety. Recent studies have shown that among chronic pain patients treated with TPU, their mood improved after treatment.

“There are infinite possibilities hidden behind every innovative technology, and the truth often requires continuous experiments and research to reveal.”

With the continuous advancement of science and technology and the deepening of research, the application prospects of low-frequency ultrasound will gradually become clearer. In the future, will this technology be the key to changing the next chapter of medical care?

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