Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring

Abstract

Key Points Question What is the risk of attention-deficit/hyperactivity disorder in children prenatally exposed to valproate and other antiepileptic drugs? Findings In a population-based cohort study of 913\u2009302 children in Denmark, prenatal exposure to valproate was significantly associated with a 48% increased risk of attention-deficit/hyperactivity disorder compared with children with no valproate exposure. No association was identified for other antiepileptic drugs. Meaning The findings of this study corroborate that counseling is appropriate for the use of valproate in pregnancy and in women of childbearing potential.