JAMA Network Open | 2021
Disparities by Race and Ethnicity Among Adults Recruited for a Preclinical Alzheimer Disease Trial
Abstract
Key Points Question Are there racial/ethnic differences associated with recruitment sources and reasons for ineligibility among preclinical Alzheimer disease clinical trial participants? Findings In this cross-sectional study of screening data for 5945 participants from a preclinical Alzheimer disease trial, Black, Hispanic, and Asian participants were recruited from local efforts compared with White participants who were recruited from more distributed efforts. Adjusted analysis showed that underrepresented racial/ethnic communities were more likely to be ineligible after the first screening visit. Meaning These findings suggest that there are racial and ethnic disparities in preclinical AD clinical trial enrollment that will require a comprehensive approach to study design and recruitment strategies to minimize disproportionate enrollment.