Association Between Periconceptional Weight of Maternal Grandmothers and Attention-Deficit/Hyperactivity Disorder in Grandchildren

Abstract

Key Points Question Is there an association of grandmother prepregnancy body mass index or gestational weight gain with risk of attention-deficit/hyperactivity disorder (ADHD) among grandchildren? Findings This cohort study of 19\u2009835 grandmother-mother dyads indicated independent, significant associations of grandmother underweight and mother overweight or obesity prior to pregnancy with higher odds of ADHD among 44\u2009720 children in the following generation. Meaning The present study findings suggest that underweight grandmaternal periconceptional body mass index may be associated with ADHD among grandchildren, potentially via the germline.