Design of multifunctionalized piperazine polymer and its activity toward pathogenic microorganisms

Abstract

The study intends to design a simple and powerful synthesis of piperazine-methacrylate monomer and its homopolymer. \nThe synthesized piperazine-methacrylate monomer was polymerized by solution polymerization technique in the presence of freeradical initiator azobi (2-methylpropionitrile) resulting in the formation of multifunctionalized piperazine polymer. The structural investigation was done by FTIR and NMR (1H and 13C NMR). The thermal properties and degradation of the polymer were examined by DSC and TGA techniques. The polymer exhibited glass transition temperature (Tg) at 88.4 �C. The polymer surface was found to be soft and nonporous which was examined by FESEM. The synthesized polymeric compound exhibited good antimicrobial activity against \nGram-negative bacterium Escherichia coli, tubercular variant Mycobacterium smegmatis, and Gram-positive bacterium Staphylococcus aureus with a zone of inhibition at a range of 15.60–19.33, 15.33–17, and 15.67–18 mm diameter, respectively. The polymer also showed \ngood activity against fungus Candida albicans with a zone of inhibition at a range of 16.33–22 mm diameter. The percentage inhibition of microorganisms increased with increase in concentration (1.5–12 mg) which is carried out by optical density method. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47521.