Is periodontal phenotypic modification therapy beneficial for patients receiving orthodontic treatment? An American Academy of periodontology best evidence review.

Abstract

BACKGROUND\nOrthodontic treatment can greatly impact the periodontium, especially in dentitions with a thin periodontal phenotype. Orthodontic tooth movement can result into iatrogenic sequelae to these vulnerable anatomic conditions, such as development and exacerbation of bony dehiscence or fenestration defects, which can manifest lost of periodontal support and gingival recession (GR). This systematic review aimed to investigate whether periodontal phenotypic modification therapy (PhMT) involving in hard tissue augmentation (PhMT-b) or soft tissue augmentation (PhMT-s) has clinical benefits for patients undergoing orthodontic treatment.\n\n\nMETHODS\nAn electronic search was performed in two major databases for journals published in English language from January 1975 to January 2019 and hand search of printed journals were also screened to identify human clinical trials reporting clinical and radiographic outcomes of patients receiving orthodontic treatment with or without hard and soft tissue augmentation procedures. Data was extracted and organized into tables for qualitative assessment.\n\n\nRESULTS\nEight studies were identified evaluating the outcomes of PhMT in patients undergoing orthodontic therapy. Six studies evaluated patients receiving PhMT-b via corticotomy-assisted orthodontic therapy (CAOT) and simultaneous bone augmentation while the other two received PhMT-s prior to tooth movement. No studies investigated PhMT-b alone without CAOT and most studies focused on the mandibular anterior decompensation movements. There was high heterogeneity in the study design and inconsistency of the reported outcomes; therefore, a meta-analysis was not performed. Evidence, at this moment supports CAOT with hard tissue augmentation enhanced tooth movement. However, only two studies provided indirect evidence to support CAOT reduced the overall treatment time compared to conventional orthodontic treatment. No periodontal complications or evidence of severe root resorption were reported for both groups. Four studies provided radiographic assessment of the PhMT-b and demonstrated increased radiographic density or thicker facial bone after the treatment. Two studies reported an expanded tooth movement. One study reported an increase in keratinized tissue width (KGW) post CAOT plus PhMT-b while another study with a 10-year follow-up showed a lower degree of relapse using the mandibular irregularity index when compared to conventional tooth movement alone. Two studies examined the effect of PhMT-s prior to orthodontic treatment. Unfortunately, no conclusions can be drawn because of the limited number of studies with contradicting outcomes.\n\n\nCONCLUSIONS\nWithin the limited studies included in this systematic review, PhMT-b via particulate bone grafting together with CAOT may provide clinical benefits such as modifying periodontal phenotype, maintaining or enhancing facial bone thickness, accelerating tooth movement, expanding the scope of safe tooth movement for patients undergoing orthodontic tooth movement. The benefits of PhMT-s alone for orthodontic treatment remain undetermined due to limited studies available. PhMT-b appears promising and with many potential benefits for patients undergoing orthodontic tooth movement. There is a need for higher quality of randomized controlled trials (RCTs) or case-control studies with longer follow-up to investigate the effects of different grafting materials and surgical sites other than mandibular anterior region. This article is protected by copyright. All rights reserved.