Angewandte Chemie | 2019
Atroposelective arene formation via carbene-catalyzed formal [4+2] cycloaddition.
Abstract
Atroposelective arene formation is an efficient method to build axially chiral molecules with multi-substituted arenes. Here we report an organocatalyzed atroposelective arene formation reaction via N-heterocyclic-carbene catalyzed formal [4+2] cycloaddition of conjugated dienals andĪ±-aryl ketones. This study expands the synthetic potential of NHC organocatalysis and provides a competitive pathway for the synthesis of axially chiral ligands, catalysts and other functional molecules.