Co(III), Rh(III) & Ir(III)-Catalyzed Direct C-H Alkylation/ Alkenylation/ Arylation with carbene precursors.

Abstract

Metal carbenes\xa0plays a pivotal role in transition-metal-catalyzed synthetic transfer reactions.\xa0 The metal carbene generates either from the diazo compound through facile extrusion of N 2 with metal catalyst or in situ generate from other sources like triazoles, pyriodotriazoles, sulfoxonium ylides and iodonium-ylide. Other hand, Rh(III) & Ir(III)-Catalyzed C-H functionalization s have been well established as a key synthetic step to enable the construction of various synthetic transformations.\xa0 Interestingly, in recent years, merging of these two concepts C-H activation and carbene migratory insertion gained much more attention. Particularly, Rh(III) & Ir(III)-catalyzed arene C-H functionalization s with carbene precursors via carbene migratory insertion. Through this review, we summarize the recent advances of Rh(III) & Ir(III)-catalyzed direct C-H alkylation/ alkenylation/ arylation with carbene precursors and also discussed the key synthetic intermediates within the catalytic cycles.