Progress in gene-therapy treatments for prostate cancer.

Abstract

Prostate cancer is one of the predominant cancers affecting men and has been widely reported. In the past, various therapies and drugs have been proposed to treat prostate cancer. Among these treatments, gene therapy has been considered to be an optimal and widely applicable treatment. Furthermore, due to the increased specificity of gene sequence complementation, the targeted delivery of complementary gene sequences may represent a useful treatment in certain instances. Various gene therapies, including tumor suppressor gene therapy, suicide gene therapy, immunomodulation gene therapy and anti-oncogene therapies, have been established to treat a wide range of diseases, such as cardiac disease, cystic fibrosis,\xa0HIV/AIDS, diabetes,\xa0hemophilia\xa0and\xa0cancers. To this end, several gene-therapy clinical trials at various phases are underway. This overview describes the developments and progress in gene therapy, with a special focus being placed on prostate cancer. Prostate cancer is one of the predominant cancers in men and widely reported. Gene therapy is applicable to treat due to higher specificity of gene sequence. Gene complementation & targeted delivery were desired in several instances. Several studies are under various clinical phase trials and elucidated the developments & progresses with gene therapy in prostate cancer. This article is protected by copyright. All rights reserved.