Aureonitols A and B, Two New C13‐Polyketides from Chaetomium globosum, an Endophytic Fungus in Salvia miltiorrhiza

Abstract

Two new C13‐polyketides, aureonitols A and B (1 and 2), along with five known compounds (3–7), were isolated from the solid fermentation culture of the plant endophytic fungus Chaetomium globosum from the aerial parts of Salvia miltiorrhiza. The structures and absolute configurations of 1 and 2 were determined by comprehensive spectroscopic data analysis and computed methods. Compound 5 was found to display the remarkable antimicrobial activities against four multidrug‐resistant bacteria (Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, and Staphylococcus epidermidis) with MIC values of 3.13–6.25\u2005μg/mL (ciprofloxacin: 0.78–1.56\u2005μg/mL), and also against all tested fungal strains with MIC values of 3.13–25\u2005μg/mL (ketoconazole: 0.78–12.50\u2005μg/mL).