Chembiochem : a European journal of chemical biology | 2021
Red blood cells membrane coated metal-drug nanoparticles for enhanced chemotherapy.
Abstract
To overcome the high toxicity, low bioavailability and poor water solubility of chemotherapeutics, a variety of drug carriers have been designed. However, most of carriers severely limited by low drug loading capacity and adverse side effects. Here, a new type of metal-drug nanoparticles (MDNs) was designed and synthesized. The MDNs self-assembled with Fe(Ⅲ) ions and drugs molecules through coordination-driven resulting in nanoparticles with high drug loading. To assist systemic delivery and prolong circulation time, the obtained MDNs were camouflaged with red blood cells (RBCs) membrane as RBCs@Fe-DOX MDNs to improve stability and their dispersity. The RBCs@Fe-DOX MDNs presented pH-responsive release functionalities, resulting in the drug release accelerated in the acidic tumor microenvironments. The outstanding in vitro and in vivo antitumor therapeutic outcome was realized by RBCs@Fe-DOX MDNs. This study provides an innovative design guideline for chemotherapy and demonstrated the great capacity of nanomaterials in anticancer treatments.