Pathology of Hepatic Iron Overload

Abstract

Hemochromatosis is the group of disorders caused by systemic iron overload. These can be inherited (hereditary hemochromatosis [HH]) or secondary to a number of conditions, such as multiple blood transfusions, dyserythropoiesis, and chronic liver disease. The liver is commonly affected, and in severe cases, these disorders can lead to cirrhosis and hepatocellular carcinoma (HCC). This review will cover the histological pattern of hepatic iron overload and its diagnostic and therapeutic implications.