Cancer | 2019
Mapping child and adolescent self‐reported symptom data to clinician‐reported adverse event grading to improve pediatric oncology care and research
Abstract
Clinicians are the standard source for adverse event (AE) reporting in oncology trials, despite the subjective nature of symptomatic AEs. The authors designed a pediatric patient‐reported outcome (PRO) instrument for symptomatic AEs to support the National Cancer Institute s Common Terminology Criteria for Adverse Events (CTCAE) (the Pediatric PRO‐CTCAE). The current study developed a standardized algorithm that maps all possible Pediatric PRO‐CTCAE response patterns to recommended CTCAE grades to improve the accuracy of AE reporting in pediatric oncology trials.