ChemSusChem | 2019
Regioselective β-Arylation of α-Angelica Lactone via Isomerization/Addition under Mild Conditions.
Abstract
The conversion of biomass-based platform molecules into various high-value chemicals greatly promote the utilization of renewable biomass resources. Herein, we reported an example of Rh-catalyzed β- arylation of levulinic acid derived α -angelica lactone, providing the γ-lactone structure products with high regioselectivity. Both arylboronic and alkenylboronic acids can be applied in this transformation. This reaction tolerated a variety of synthetically important functional groups. Moreover, the obtained γ-lactone products can be readily converted to high-valuable products, such as 1, 4-diol and γ-methoxy-carboxylate.