European Journal of Pain | 2021
High‐dose spironolactone lacks effectiveness in treatment of fibromyalgia (RCT)
Abstract
Spironolactone (SPL) is a reversible mineralocorticoid receptor (MR) and androgen receptor (AR) antagonist which attracts pharmacotherapeutic interest not only because of its beneficial effects in heart failure but also because of the pathogenetic roles of MR and AR activities in neuropsychiatric diseases. Recently, beneficial and rapid‐onset effects of SPL have been documented in a case series of women with fibromyalgia syndrome (FMS). To reaffirm this observation, we performed a double‐blind placebo‐controlled randomized clinical trial (RCT).