New Glance at the Role of TM6SF2 in Lipid Metabolism and Liver Cancer

Abstract

Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the most common cause of chronic liver diseases. NAFLD can progress to more severe conditions, such as non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC), which confer increased morbidity and mortality. However, many individuals with NAFLD do not progress to these more severe conditions. Such variations in the susceptibility of NAFLD progression suggest that it is likely affected by multiple factors, in particular, genetic factors.