CLINICAL OBSERVATION OF METRONOMIC CHEMOTHERAPY COMBINED WITH CLEARING HEAT AND DETOXICATING TRADITIONAL CHINESE MEDICINE IN THE TREATMENT OF REFRACTORY AND RELAPSED ELDERLY LYMPHOMA

Abstract

≥80% ARDI (average relative dose intensity, cyclophosphamide and doxorubicin) with a prophylactic use of Peg-G-CSF (73.2% vs. 70.9%, p=0.039). Among pretreatment clinical characteristics analyzed, age over 65, female gender, ECOG performance status 2 or higher, stage IV, and albumin level less than 3.5mg/dl were related with the development of FN (Table 4.). Multivariate analysis showed that age, gender, ECOG PS and albumin level were significantly related to FN (Table 5). Conclusion: Prophylactic use of Peg-G-CSF reduced the incidence of neutropenia and FN significantly in patients with DLBCL receiving RCHOP therapy when compared to the control cohort, which resulted in the reduction of early infection-related deaths. In addition, PegGCSF support significantly improved dose-delay and ARDI. However, the patients who were elderly, female gender, with poor performance status and low albumin level still had high incidence of FN. 1. Kim SJ, Hong JS, Chang MH, Kim JA, Kwak JY, Kim JS, Yoon DH, Lee WS, Do YR, Kang HJ, Eom HS, Park Y, Won JH, et al. Highly elevated serum lactate dehydrogenase is associated with central nervous system relapse in patients with diffuse large B-cell lymphoma: results of a multicenter prospective cohort study. Oncotarget. 2016;7:72033-43. 2. Hong JS, Kim SJ, Chang MH, Kim JA, Kwak JY, Kim JS, Yoon DH, Lee WS, Do YR, Kang HJ, Eom HS, Park Y, Won JH, Mun YC, Kim HJ, Kwon JH, Kong JH, Oh SY, Lee S, Bae SH, Yang DH, Jun HJ, Lee HS, Yun HJ, Lee SI, Kim MK, Yi JH, Lee JH, Kim WS, Suh C. Improved prognostic stratification using NCCNand GEMTAMOinternational prognostic index in patients with diffuse large B-cell lymphoma. Oncotarget. 2017;8:92171-82.