Effects of PMS50 supplementation on psychological symptoms of students with premenstrual syndrome.

Abstract

OBJECTIVE\nTo evaluate the effects of PMS50 supplementation on psychological symptoms in students of AJUMS, Iran.\n\n\nMETHODS\nThis double-blind clinical trial was conducted at Ahvaz Jundishapur University of Medical Sciences, between December 2018 and March 2019. 50 female students with moderate to severe PMS randomly received either 550 mg/d of PMS50 or placebo (n=25), starting from one week before till the end of menstruation for three consecutive menstrual cycles. Anthropometric indices, dietary intake, physical activity level and severity of PMS were assessed at baseline and post-intervention. Data were analyzed by SPSS (version 22). Independent t-test was used to compare the results between groups. Paired t-test was used to compare the results within groups before and post study.\n\n\nRESULTS\nThere was a significant improvement in psychological symptoms including depression, anger, feeling of hopelessness, desire to be alone, mood swings, irritability, anxiety and poor concentration observed in intervention group compared with control group post-intervention. Restlessness was significantly reduced in both groups post-intervention. The mean scores of low self-esteem, change in appetite and food cravings were decreased in both groups, but not significant between groups.\n\n\nCONCLUSION\nPMS50 supplementation may be effective in improvement of psychological symptoms in PMS.