A novel prognosis and segmentation of necrosis (dead cells) in contrast enhanced T1‐weighted glioblastoma tumor with automatic contextual clustering

Abstract

In recent years, mortality rate with high‐grade tumor has been increased significantly especially with glioblastoma (GBM) brain tumor while compared to other malignant brain tumor. Here, the amount of dead cells accommodated with the tumor tissue in GBM brain tumor play a vital task and necessitate an earlier diagnosis of malignancy with the GBM tumor. It inspires to implement new automatic diagnosis system which detects the dead cells and tumor tissue with the GBM brain tumor, such that the survival rate of the diseased can easily be prognosis by the Radiologist and Neurosurgeon. The main objective of this article is to detect the amount of dead cells with respect to tumor tissue associated with the GBM brain tumor which desires the impact factor of the brain tumor. In this framework, initially, the new contrast enhancement modality is incorporated to enhance the gray information over the dead cells and the tumor tissue with the T1‐weighted MRI GBM brain tumor. In this enhancement, the edges of the tumor cells and its dead cells are magnified efficiently. As the noises and outliers with MR image is unpredictable and it experiences the variable amount of noises over the local window, the contextual information over each pixel of the image is adaptively modified with respect to the amount of noise over local window using adaptive contextual clustering. The performance evaluation of the framework is investigated which exhibits the overwhelming result compared to conventional detection techniques.