Association of Fc gamma‐receptor genes polymorphisms with chronic periodontitis and Peri‐Implantitis

Abstract

This study was conducted on 87 patients with chronic periodontitis (CP), 50 patients with peri‐implantitis and 90 periodontally healthy individuals referring to the Department of Periodontics for evaluating the association between Fc gamma‐receptor genes polymorphisms with CP and peri‐implantitis. After obtaining consent, venous blood samples (5cc) were obtained from patients and DNA was extracted using Miller s salting‐out method. Polymerase chain reaction (PCR)‐restriction fragment length polymorphism and tetra‐primer amplification refractory mutation system‐PCR methods were used to assess the polymorphisms of FcγRs IIa, IIIa, and IIIb genes. Analyzing showed a significant association between specific genotypes with increasing CP and peri‐implantitis risks in codominant and dominant models. For FcγR IIIa, analyzing revealed a significant association between specific genotypes with increasing CP and peri‐implantitis risks in codominant, dominant, and recessive models. For FcγR IIIb, we also detected a significant association between specific genotypes with increasing CP and peri‐implantitis risks in codominant, dominant, and recessive models ( P\u2009<\u20090.05). According to the results of this study, the FCGRIIa (rs1801274), FCGRIIIa (rs396991), and FCGRIIIb (rs1050501) polymorphisms were significantly associated with CP and peri‐implantitis and may have a role in the pathogenesis of these diseases.