Cross‐Scanner Harmonization of Neuromelanin‐Sensitive MRI for Multisite Studies

Abstract

Neuromelanin‐sensitive magnetic resonance imaging (NM‐MRI) is a validated measure of neuromelanin concentration in the substantia nigra–ventral tegmental area (SN–VTA) complex and is a proxy measure of dopaminergic function with potential as a noninvasive biomarker. The development of generalizable biomarkers requires large‐scale samples necessitating harmonization approaches to combine data collected across sites.