Issue Information ‐ TOC

Abstract

In this paper, surgical pathology records of consecu ve 2582 biopsies in 2552 breast cancer pa ents were reviewed, intraopera ve frozen sec on (FS) diagnosis was compared to postopera ve paraffi n reports. In 2235 cases whose risk of sen nel lymph node metastasis could be calculated via Memorial Sloan Ke ering Cancer Center (MSKCC) Nomogram, we found the false-nega ve rate and MSKCC risk were nega vely correlated, the axilla reopera on rates were signifi cantly decreased if FS was done. When pa ents were divided into four groups according to quar le MSKCC risk, the axilla re-excisional rates were 16.7%, 25.1%, 38.7%, and 58.7%, and number needed to treat to avoid secondary axillary clearance correspondingly decreased from 8.1, 4.6, 3.0 to 1.8. We proposed an easy and viable method by stra fi ed decision-making algorithm based on MSKCC predic on model to improve the eff ec veness of FS to avoid axillary reopera on in pa ents undergoing sen nel lymph node biopsy.