Therapeutic strategies for systemic therapies of human papillomavirus‐related oropharyngeal cancer

Abstract

Our understanding of human papillomavirus (HPV)‐related oropharyngeal cancer (OPC) and its molecular basis continues to evolve and produce important insights into customized therapeutic strategies. Novel therapeutics exploiting HPV‐related targets are being evaluated in the incurable setting, while the favorable prognosis of locoregionally advanced disease has stimulated investigation into de‐escalation strategies. There is much opportunity for better personalization of standard therapy according to HPV status. This review discusses both current and investigational therapeutic strategies for HPV‐related OPC.