Movement Disorders Clinical Practice | 2019
A Rare Presentation of Paraneoplastic Striatal Encephalitis Associated with Nonsmall Cell Lung Cancer
Abstract
Paraneoplastic striatal encephalitis (PSE) is relatively unusual, accounting for only 1% of all paraneoplastic neurological syndromes. PSE is usually found in association with the presence of onconeural anti-CV2/collapsin response mediator protein (CRMP) 5 (64%) and/or anti-Hu antibodies and small cell lung cancer. Hyperintensity in the basal ganglia (BG) is often evident on T2-weighted and fluid attenuated inversion recovery (FLAIR) sequences in magnetic resonance imaging (MRI). Herein, we report a case of “antibody negative” PSE as the initial presentation of nonsmall cell lung cancer (NSCLC).