Molecular Genetics & Genomic Medicine | 2019
HDAC4 mutations cause diabetes and induce β‐cell FoxO1 nuclear exclusion
Abstract
Studying patients with rare Mendelian diabetes has uncovered molecular mechanisms regulating β‐cell pathophysiology. Previous studies have shown that Class IIa histone deacetylases (HDAC4, 5, 7, and 9) modulate mammalian pancreatic endocrine cell function and glucose homeostasis.