Editorial

Abstract

Enclosed you will fi nd Edition 40 (6). Continued progress with pandemic related issues is being evidenced by some degree of viral impact reduction, and as growing numbers are vaccinated the hope of signifi cant population immunity levels is closer to reality. In the review section, Wuytach et al perform a systemic review on quality of life and utility measures in women with stress urinary incontinence and identify the IQol as being the most robust measure identifi ed. Zacharakis and colleagues systematically review pelvic fl oor reconstruction done under local anesthesia and fi nd this option a reasonable and effi cient alternative anesthetic choice for women undergoing surgery for stress urinary incontinence and less so for more involved pelvic reconstruction. Trinchieri and associates, again using systematic review process, evaluate psychotropic drugs and their eff ects on the lower urinary tract and note that tricyclic antidepressants and SNRIs both have a higher association of voiding dysfunction thus necessitating a careful history and evaluation when developing treatment strategy. Hoe and group review extend evidence for urethral bulking agents and fi nd little long-term data except for two agents with only one agent having long-term safety data being reported. Law et al report the evidence variances in surgical and functional outcomes for patients undergoing surgery for lower urinary tract symptoms related to BPH versus those undergoing intervention for retention due to BPH. They noted similar functional outcomes between the two groups, however a persistent higher risk for permanent catheterization was noted in the retention group. Tsiapakidou and associates rigorously evaluate clinical practice guidelines on pelvic organ prolapse using a new validated tool, AGREE II and determine that substantial variations in quality and defi ciencies exist. Jackson and colleagues utilize bibliometric analysis of the fi eld of electrical neuromodulation for bladder dysfunction specifi cally focusing on the top 100 cited articles and notice improved outcomes reporting and focused outcomes reporting in certain journals. Giagio and associates assess extant controlled trials related to pelvic fl oor muscle training in women with pelvic organ prolapse and associated completeness of exercise reporting. Gerig at al determine that in general women with OAB are dissatisfi ed with current options for treatment of the condition and that electrical stimulation with tibial nerve modulation may provide better balance for patient centered care delivery. In the basic science section, Roy and colleagues study the value of MRI determination of continent women using diff usion tensor imaging and fi ber tractograhy for pelvic MRI reconstruction. Liu and group study the eff ect of activation of TRPM8 channel and subsequent inhibition of contraction of isolated human ureter. Kwon and associates identify the value of anti-fi brosis modulation using a variety of receptor modulators for bladder wall remodeling and detrusor overactivity in rodents with spinal cord injury. Turner et al Study the eff ects of radiation therapy on rodent bladder contractility and muscle morphology and identify decrease muscular contractility and changes in axonal profi les and smooth muscle content within the bladder muscle wall. Burnett and research consortium attempt to phenotype urinary tract infection based upon diff erences in urobiome composition. In the clinical section, Baka-Ostrowka et al determine the safety and effi cacy of mirabegron in children. Seddone and associates note the high prevalence of lower urinary tract symptoms in women with multiple sclerosis and the signifi cant impact on their quality of life. Santis-Mayo and colleagues identify a high incidence of common voiding dysfunction associated with overactive bladder including evidence of outlet obstruction as well as detrusor underactivity and suspect that nighttime frequency may be an indicator of these concomitant problems. Dmochowski, Haab, and Robinson evaluate placebo controlled trials related to a new centrally acting compound known as litoxetine. Ross et al fi nd that 75% improvement urinary symptoms after neuromodulation trial is a better indicator of long-term effi cacy that is 50% improvement. Soytas and colleagues identify the importance of hand grip strength as an indicator of pelvic fl oor muscle strength in women with pelvic fl oor dysfunction. Cowley, Staff ord, and Hodges valuate transperineal pelvic fl oor ultrasound both before and after prostatectomy for repeatability and identify the feasibility of same. Tillier and Group utilize a continence prediction tool in a historical control cohort and a prospective cohort and fi nd value of same for patient informed consent and mutual decision making. Wagg and consortium perform a post hoc analysis of antimuscarinic treatment with a particular agent and fi nd 1/3 of patients report a 50% urgency reduction and 3⁄4 reported at least a 50% resolution of incontinence at 12 months with few patients reporting total continence resolution. Moon et al use the NHANES database to link the relationship between nocturia and cardiovascular disease and fi nd increasing vascular disease associated with increasing DOI: 10.1002/nau.24749