Dexmedetomidine Infusion Therapy

Abstract

Dexmedetomidine (4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, is a highly potent, selective α2-adrenergic receptor agonist with sedative, analgesic and anxiolytic properties. Although primarily used for sedation in adult intensive care unit patients, novel applications have emerged in the literature, with favorable results in the prevention of delirium, acute postoperative pain, and opioid induced hyperalgesia, amongst others. Dexmedetomidine exerts its action by binding to α2A-, α2B-, and α2C-adrenoceptors, producing plasma concentration-dependent hypotension and bradycardia without respiratory depression.