Repetitive Fistulizing Lymphadenopathy and Hematochezia

Abstract

Three major categories of primary immunodeficiency can predispose to BCG infection: 1) severe combined immunodeficiency, 2) innate phagocytic defects as in chronic granulomatous disease, and 3) Mendelian susceptibility to mycobacterial diseases (MSMD) \n \n \nIL-12Rβ1 deficiency is the most common underlying defect in MSMD \n \n \nMSMD confers susceptibility to non-tuberculous mycobacteria, as well as Mycobacterium bovis in BCG, Salmonellae, and selected viral and Candida infections \n \n \nSever salmonella infections might be the initial or sole presenting feature in MSMD