Archive | 2019
Hematologic Malignancy Biomarkers in Proximal Fluids
Abstract
Key Topics \n \n \nMolecular genetics of hematologic malignancies \n \n \nBiology of noncoding transcripts in hematologic malignancies \n \n \nBiomarkers of hematologic malignancies in proximal fluid (blood) \n \n \nEmerging roles of extracellular vesicles in hematologic malignancies \n \n \n \n \nKey Points \n \nCollectively, hematologic malignancies ranked among the top five cancers diagnosed globally in 2018. \n \n \nLeukemia and non-Hodgkin lymphoma are the most common hematologic malignancies. \n \n \nA common genetic hallmark of hematologic malignancies is chromosomal aberrations that in association with mutations alter signaling pathways. \n \n \nExtracellular vesicles and their cargo, especially noncoding RNA, play important roles in the pathology of hematologic malignancies. \n \n \nThe genetic alterations in hematologic malignancies are detectable noninvasively in cell-free DNA, which when validated should obviate the need for invasive biopsies under some circumstances for disease management.