P50 and P300 Event Related Potentials in Patients with Schizophrenia Recorded from High-Density EEG

Abstract

The main objectives of this study were to describe P50 and P300 cortical topography in patients with schizophrenia and to define a robust methodology of signal quantification using high density EEG. Within a clinical trial in which patients with schizophrenia and auditory verbal hallucinations were submitted to 10 days rTMS treatment, P50 and P300 were investigated as possible neurophysiological measurements to assess treatment effectiveness together with psychometric scales like Psychotic symptom rating scale (PSYRATS), depression, anxiety and stress scale (DASS) and Quality of Life scale (QoL). Here we describe the technique of collecting P50 and P300 using high-density EEG and we reproduce the preliminary data of P300 in one healthy subject and P50 in two patients and two healthy subjects.