Hereditary Optic Neuropathy

Abstract

Hereditary optic neuropathies are a cluster of disorders that can present with sudden, subacute, or slowly progressive visual decline, typically affecting the central vision and color vision. While they can be inherited in autosomal dominant, autosomal recessive, or maternal patterns, they share a common mechanism of mitochondrial dysfunction. There are no proven treatments, but there are some accepted supportive measures, as well as the option for preimplantation genetic testing in combination with in vitro fertilization.