Computer Modelling for Nutritionists

Abstract

ions. A pertinent example is hepatic cholesterol synthesis. The rate law governing cholesterol synthesis and its regulation is an abstraction summarizing the multitude of steps involved in cholesterol biosynthesis. The stages are outlined in the SBGN representation of cholesterol biosynthesis in Fig. 4.7. It is known cholesterol biosynthesis is regulated homeostatically. This type of regulation employs negative feedback to counteract increased levels of hepatic free cholesterol. To model this, a function which captures the regulation of cholesterol synthesis by hepatic free cholesterol is needed. The equation I derived to represent this is similar to a Hill function and it is outlined in Eq. 4.1. Where Hepatic cholesterol synthesis = ( HCSmax 1 + (HFC/HCSt )HS )