Alternative Corneal Cross-Linking Agents

Abstract

Corneal cross-linking can be performed by chromophores that produce reactive oxygen radicals when exposed to illumination at a specific wavelength or chemically without light application. The clinically applied and most widely studied is riboflavin that is activated by UVA light. Other chromophores under investigation are Rose Bengal and Eosin Y which are excited by green light and WST-D that is activated by near infrared light. Agents that induce cross-linking chemically are Genipin and Galacorin.