Direction of information flow between brain regions in ADHD and healthy children based on EEG by using directed phase transfer entropy

Abstract

Directed information flow between brain regions might be disrupted in children with Attention Deficit Hyperactivity Disorder (ADHD) which is related to the behavioral characteristics of ADHD. This paper aims to investigate the different information pathways of brain networks in children with ADHD in comparison with healthy subjects. EEG recordings were obtained from 61 children with ADHD and 60 healthy children without neurological disorders during attentional visual task. Effective connectivity among all scalp channels was calculated using directed phase transfer entropy (dPTE) for delta, theta, alpha, beta, and lower-gamma frequency bands. Group differences were evaluated using permutation tests in connectivity between regions. Significant posterior to anterior patterns of information flow in theta frequency bands were found in healthy subjects (p-value\u2009<\u20090.05), while disrupted pattern flow, in an opposite way, was found in ADHD children. In the beta band, information flow in pathways between anterior regions was significantly higher in healthy individuals than in the ADHD group. These differences are more indicated in connectivity that leads from frontal and central regions to the right frontal regions of the brain (F8 electrode). Furthermore, connections from central and lateral parietal areas to Pz electrode areas are statistically significant and higher in healthy children in this band. In the delta band, internal connections in the anterior region show a significant difference between the two groups, as this amount is higher in the ADHD group. Our analysis may provide new insights into information flow in brain regions of ADHD children in comparison with healthy children.