Short-time total-body dynamic PET imaging performance in quantifying the kinetic metrics of 18F-FDG in healthy volunteers

Abstract

To investigate the performance of short-time dynamic imaging in quantifying kinetic metrics of 2-[18F]-fluoro-2-deoxy-d-glucose (18F-FDG). Dynamic total-body positron emission tomography (PET) imaging was performed in 11 healthy volunteers for 75 min. The data were divided into 30-, 45- and 75-min groups. Nonlinear regression (NLR) generated constant rates (k1 to k3) and NLR-based Ki in various organs. The Patlak method calculated parametric Ki images to generate Patlak-based Ki values. Paired samples t-test or the Wilcoxon signed-rank test compared the kinetic metrics between the groups, depending on data normality. Deming regression and Bland–Altman analysis assessed the correlation and agreement between NLR- and Patlak-based Ki. A two-sided P\u2009<\u20090.05 was considered statistically significant. The 45- and 75-min groups were similar in NLR-based kinetic metrics. The relative difference ranges were as follows: k1, from 3.4% (P\u2009=\u20090.627) in the spleen to 57.9% (P\u2009=\u20090.130) in the white matter; k2, from 6.0% (P\u2009=\u20090.904) in the spleen to 60.7% (P\u2009=\u20090.235) in the left ventricle (LV) myocardium; k3, from 45.6% (P\u2009=\u20090.302) in the LV myocardium to 96.3% (P\u2009=\u20090.478) in the liver; Ki, from 14.0% (P\u2009=\u20090.488) in the liver to 77.8% (P\u2009=\u20090.067) in the kidney. Patlak-based Ki values were also similar between these groups in all organs, except the grey matter (9.6%, P\u2009=\u20090.029) and cerebellum (14.4%, P\u2009=\u20090.002). However, significant differences in kinetic metrics were found between the 30-min and 75-min groups in most organs both in NLR- and Patlak-based analyses. The NLR- and Patlak-based Ki values significantly correlated, with no bias in any of the organs. Dynamic imaging using a high-sensitivity total-body PET scanner for a shorter time of 45 min could achieve relevant kinetic metrics of 18F-FDG as done by long-time imaging.