Recovery of pad-free continence in elderly men does not differ from younger men undergoing robot-assisted radical prostatectomy for aggressive prostate cancer

Abstract

Purpose To analyze urinary continence outcome following robot-assisted radical prostatectomy (RARP) for aggressive prostate cancer in men aged\u2009≥\u200970 and\u2009<\u200970\xa0years. Methods Retrospective analyses of prospectively collected long-term data from a monocentric cohort of 350 men with D’Amico high-risk prostate cancer undergone robot-assisted radical prostatectomy at a single institution between 2005 and 2016. The association between time since operation and zero-pad urinary continence recovery was comparatively analyzed by separate pre-operative and post-operative Cox proportional-hazard regression models. Results Median age in the age group\u2009≥\u200970\xa0years was 73\xa0years compared with 62\xa0years in the\u2009<\u200970\xa0year age group. Distribution of men receiving adjuvant and salvage radiotherapy/hormonal therapy was similar in both age groups. Urinary continence recovery rate at 12, 24, and 36\xa0months after surgery of men aged\u2009≥\u200970\xa0years was 66, 79 and 83%, respectively, and statistically similar to that of men\u2009<\u200970\xa0years: 71, 81, and 85% (log-rank test p \u2009=\u20090.24). Multivariable analyses demonstrated no significant difference in return to continence between the two age groups ( p \u2009=\u20090.28 and p \u2009=\u20090.17). In addition, clinical stage and type of nerve sparing (unilateral, bilateral or non-nerve sparing) were found to be independently predictive of pad-free continence recovery. Conclusions Regardless of age, return to continence in men with aggressive prostate cancer undergoing RARP continues to improve way beyond the first 12\xa0months after surgery. Considering the dire effects of post-operative radiotherapy on continence in this aggressive cancer cohort, advanced age alone should not discourage recommending multimodal therapy involving RARP.