The effectiveness of inositol and metformin on infertile polycystic ovary syndrome women with resistant to letrozole

Abstract

AbstractPurposeThe purpose is a comparison of effectiveness of myo-inositol and metformin in infertile women with polycystic ovary syndrome (PCOS) treated with letrozole.MethodsThis study is a randomized single-blind controlled clinical trial\n undertaken in 150 infertile PCOS women. For all patients, letrozole is prescribed at a dose of 7.5\xa0mg per day from the third day of menstruation for 5\xa0days. Patients who did not ovulate were included and divided into three pretreatment groups: group I(control group), 200\xa0µg of folic acid (as a placebo); group II, 1500\xa0mg of metformin daily plus 200\xa0µg of folic acid, and group III, inositol 2\xa0g plus 200\xa0µg of folic acid received twice daily for 3\xa0months. In the last cycle, 7.5\xa0mg letrozole was prescribed for the induction of ovulation. Primary outcomes were ovary function and pregnancy.ResultsThe ovarian function was not significantly different in those groups, whereas the ovarian function of inositol + folic acid group in normal BMI found significantly higher than other BMI spectra. In addition, the ovarian function is significantly higher in the inositol + folic acid group by increasing the infertility duration. The incidence of pregnancy is lower in letrozole + folic acid + inositol group than the other groups; however, it is not significant.ConclusionThe addition of inositol and metformin to the treatment of infertile PCOS women with letrozole resistance improves the ovarian function; however, it is not significant. Of note, inositol was more effective than metformin in patients with normal BMI.IRCT registration numberIRCT2017070234845N1