Archives of Gynecology and Obstetrics | 2021
Polymorphisms of vascular endothelial growth factor and recurrent implantation failure: a systematic review and meta-analysis
Abstract
To investigate the associations between polymorphisms of vascular endothelial growth factor (VEGF) with recurrent implantation failure (RIF). We performed the systematic review and meta-analysis by searching databases of PubMed, EMBASE, OVID, and CNKI (China National Knowledge Infrastructure) for studies that evaluated the associations between VEGF polymorphisms with RIF. Meta-analysis was performed if the polymorphism was studied by more than two case–control studies. Data were analyzed using R software. Odds ratios (ORs) with 95% confidence intervals (CIs) were reported to assess the associations. Nine VEGF polymorphisms (−1154G\u2009>\u2009A, −460T\u2009>\u2009C,\u2009+405G\u2009>\u2009C, −7C\u2009>\u2009T, −634C\u2009>\u2009G, −2578C\u2009>\u2009A,\u2009+936C\u2009>\u2009T, 5C\u2009>\u2009T, −583C\u2009>\u2009T) were systematically reviewed. Meta-analysis was performed on VEGF −1154 G\u2009>\u2009A polymorphism. Three case–control studies consisted of 683 women were included in the quantitative meta-analysis (305 RIF patients and 378 controls). Results showed that VEGF −1154A allele was significantly associated with RIF (OR 1.39, 95% CI 1.08–1.78, P-value\u2009=\u20090.01). The dominant genetic model showed that VEGF 1154AA plus VEGF 1154AG genotypes were more frequent in RIF patients than VEGF 1154GG genotype (OR 1.56, 95% CI 1.10–2.20, P-value\u2009=\u20090.01). However, the result under the recessive genetic model showed no significant difference (OR 1.67, 95% CI 0.92–3.03, P-value\u2009=\u20090.09). VEGF −1154A allele may serve as one of the predisposing factors of RIF. Women with VEGF 1154 AA/GA genotypes were at higher risk of RIF. However, we should consider the haplotype effect of VEGF polymorphisms in future studies.