Journal of Neural Transmission | 2019

Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder



The SNP rs2251214 of the SYT1 gene was recently associated with externalizing phenotypes, including ADHD and cocaine use disorder (CUD). Here, we investigated whether SYT1-rs2251214 could also be implicated with cognitive performance variations among women with CUD. Results showed that G homozygous (n\u2009=\u2009146) have lower cognitive performance in the Stroop, Trail Making and Matrix Reasoning tests compared with A-allele carriers (n\u2009=\u200964), suggesting that rs2251214 may influence the severity of cognitive impairments in CUD.

Volume 126
Pages 1707-1711
DOI 10.1007/s00702-019-02086-w
Language English
Journal Journal of Neural Transmission

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