Efficient synthesis of 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives catalyzed by functionalized nanoporous silica

Abstract

An efficient and facile method has been developed for the synthesis of various 6,6 a -dihydroisoindolo[2,1- a ]quinazoline-5,11-dione derivatives, via a three-component reaction of 2-amino- N -(R)-benzamide derivatives with 2-formylbenzoic acid using sulfonic acid functionalized nanoporous silica as an efficient catalyst in ethanol under reflux. High yield of the desired products, reusability of the catalyst, and effortless workup step without using chromatography are the advantages of this method. Graphic abstract